ABSTRACT
Purpose@#This study aimed to examine the effects of self-efficacy, social support, self-esteem, and depressive symptoms on physical activity in midlife and old-aged women with depression. @*Methods@#Midlife and old women (N=83) diagnosed with depression were recruited from the psychiatry outpatient clinic in Seoul. Data were collected via self-report measures, and they were analyzed using descriptive statistics, Pearson correlation coefficients, and hierarchical multiple linear regression. @*Results@#Physical activity had significant positive correlations with self-efficacy, social support, and self-esteem, and it had a significant negative correlation with depressive symptoms. In the hierarchical multiple regression model of physical activity (adjusted R2=.34, p=.003), self-efficacy (β=.47, p<.001) and depressive symptoms (β=-.42, p=.003) were statistically significant. @*Conclusion@#Self-efficacy and depressive symptoms are important factors influencing physical activity in midlife and old women with depression. To improve the physical activity of this population, nursing interventions should aim to promote self-efficacy and alleviate depressive symptoms.
ABSTRACT
Background and Objectives@#The association between multifocal papillary thyroid carcinoma (PTC) and tumor aggressiveness remains controversial. The aim of study is to evaluate molecular subtypes of multifocal PTCs using multiplatform genomic analysis. @*Materials and Methods@#Statistical analysis and genomic analysis were performed for gene expression data and clinical data of multifocal PTCs in The Cancer Genome Atlas data. Clinicopathologic findings, recurrence-free survival (RFS), copy number alteration and somatic mutation status in patients in relation to molecular subtypes were analyzed. @*Results@#Multiplatform genomic analysis revealed that multifocal PTCs (n=226) were divided into two distinct molecular subgroups. Participants in cluster 2 showed significantly increased risk of extrathyroidal extension, lymph node metastasis, and BRAFV600E mutation compared to patients in cluster 1. To exclude the effect of BRAF mutation and RAS mutation on tumor aggressiveness, we compared clinical parameters between two clusters in patients without BRAF or RAS mutation. Cluster 2 showed significantly higher risk of lymph node metastasis compared to cluster 1. @*Conclusion@#Multifocal PTC has two distinct molecular subtypes with distinctive clinical behaviors. Our data suggested the clinical implications of the transcriptomic signature to predict clinical outcomes of multifocal PTC.