Research progress on the occurrence and characteristics of CD8+T cell exhaustion and its relationship with tumor immunotherapy resistance / 中国肿瘤临床

Immune checkpoint inhibitors(ICIs)have emerged as important targets of treatment for various types of cancers,yet drug resist-ance poses considerable problems.Tumor immunotherapy resistance is closely related to the tumor microenvironment(TME).Exhaustion of CD8+T cells in the TME continuously express high levels of inhibitory receptors(IRs)and play a central role in ICIs resistance.Targeting IRs provides new prospects for overcoming immunotherapy resistance.This review focuses on the occurrence and characteristics of CD8+T cell exhaustion and explores its association with tumor immunotherapy resistance.