ABSTRACT
The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
Subject(s)
Humans , Crohn Disease/drug therapy , Antibodies, Monoclonal/therapeutic use , Time Factors , Remission Induction , Brazil , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Treatment Outcome , Drug Therapy, Combination , Antibodies, Monoclonal, Humanized/therapeutic use , Certolizumab Pegol/therapeutic use , Adalimumab/therapeutic use , Ustekinumab/therapeutic use , Infliximab/therapeutic use , Clinical Decision-MakingABSTRACT
Estudo de revisão baseado nos dados recentes publicados sobre a maior eficácia dos agentes biológicos, anti-TNF, frente à terapia convencional no tratamento da Doença Inflamatória Intestinal [DII], podendo mudar o curso da doença. Estudos compararam pacientes tratados com a terapia convencional (stp-up), em relação aos submetidos a uma abordagem precoce dos biológicos, a top-down. Revisado eficácia e segurança desta terapia, assim como a percepção do paciente de seu custo/ benefício.