ABSTRACT
A sialolitíase é caracterizada pela formação de cálculos (sialolitos) no sistema de ductos das glândulas salivares, provocando estase salivar e podendo acarretar a subseqüente dilatação da glândula salivar envolvida. Os sialolitos são formados por substâncias orgânicas e inorgânicas e sua patogênese permanece desconhecida, sendo duas hipóteses propostas. A primeira baseia-se na existência de microcálculos intracelulares que se acumulam com o passar do tempo e obstruem o ducto salivar. A segunda sugere que restos alimentares e bactérias presentes na cavidade oral migrariam para dentro dos ductos salivares causando a obliteração dos mesmos. Atualmente, existem várias formas de diagnóstico e tratamento dos episódios de sialolitíase, incluindo a excisão cirúrgica e a sialoendoscopia intervencional. O objetivo deste trabalho é apresentar a excisão cirúrgica de um cálculo de grandes proporções localizado no ducto da glândula submandibular em um paciente com queixa de dores constantes na região mandibular direita, elevação do assoalho bucal, diminuição da secreção de saliva e discreto desvio da língua. O procedimento cirúrgico foi o tratamento de escolha com total excisão do cálculo e posterior reconstrução do ducto. O pós-operatório de 18 meses mostrou fluxo salivar normal e ausência de recidiva.
Sialolithiasis is characterized by the formation of calculi (sialoliths) inside salivary glands duct system resulting in salivary ectasia and subsequent salivary gland dilation. Calculi are composed of organic and inorganic substances with its pathogenesis remaining unknown. Two main hypotheses are proposed: one consists of accumulation of pre existence intracellular micro calculi that accumulates in the course of time. The second theory suggests that aliments and bacteria presents inside the oral cavity migrate into the salivary ducts cause its obstruction. After clinical and/or radiographic sialolithiasis diagnosis different treatment modalities may be performed to treat this condition including surgical excision followed by ductal reconstruction or interventional sialendoscopy. The aim of this presentation is to demonstrate surgical excision of a large submandibular duct calculus in a patient complaining of constant pain at right mandible region, mouth floor elevation, diminish of salivary secretion, and slight tongue deviation. Surgical excision was conduct with totally calculi extirpation and submandibular duct reconstruction. Normal submandibular salivary flow was observed after 18 months of follow-up with no recurrence episodies.
ABSTRACT
Several materials and techniques have been proposed to improve alveolar wound healing and decrease loss of bone height and thickness that normally follow dental extraction. The objective of this research was the histologic analysis of bone morphogenetic proteins implanted into dental alveoli of rats after extraction. A total of 45 adult male Wistar rats were divided into three groups of 15 animals each: control (no treatment), implanted with pure hydroxyapatite (HA, 3 mg) and implanted with hydroxyapatite plus bone morphogenetic proteins (HA/BMPs, 3 mg). Five animals from each group were sacrificed at 7, 21 and 42 days after extraction for the histometric analyses of the osteoconductive potential of hydroxyapatite associated or not with BMPs. After dissection, fixation, decalcification and serial microtomy of 6-µm thick sections, the samples were stained with hematoxylin-eosin for histologic and histometric analyses. Both HA and HA/BMPs caused a delay in wound healing compared to control animals, evaluated by the percentage of bone tissue in the alveoli. The treatment with HA/BMPs had the greatest delay at 21 days, even though it produced values similar to the control group at 42 days. The materials did not improve alveolar repair in the normal period of wound healing and the association of HA/BMPs did not have osteoconductive properties with granulated hydroxyapatite as the vehicle
Subject(s)
Animals , Male , Rats , Alveolar Bone Loss , Wound Healing , Durapatite , Bone Morphogenetic Proteins/pharmacology , Bone Regeneration , Drug Implants , Rats, Wistar , Tooth SocketABSTRACT
La administración de albendazol (5mg/kg/día) a ratas Wistar en el 9º, 10º y 11º día de preñez, causó retardo de crecimiento intrauterino de fetos y placentas y disminución de la longitud de los cordones umbilicales. El epitelio de la mucosa lingual reveló disminución de espesor, con células mayores y menos numerosas. La región dorsal posterior de la mucosa lingual de los fetos del grupo tratado, no presentó queratina. El epitelio de la región ventral de la mucosa lingual no presentó capas granulosa ni córnea. Los resultados obtenidos mediante métodos cariométricos permiten sugerir que el epitelio de la mucosa lingual de los fetos del grupo tratado con albendazol, presenta aspectos de inmadurez y retardo de la diferenciación celular.