Endometriosis, a modern syndrome.

The identification of endometriosis has been a subject of intense debate over the last decade. There is, however, no doubt that Thomas Cullen was the first to describe endometriosis and adenomyosis as one disease characterized by the presence of endometrium-like tissue outside the uterine cavity. With the introduction of laparoscopy in the early 1960s three different clinical presentations of endometriosis were distinguished: peritoneal, deep adenomyotic and cystic ovarian. As soon as synthetic steroids became available, pioneer clinicians started utilizing these in an attempt to replace radical surgery by a medical treatment. While medical therapy may resort in relief, in most cases the current approach consists of a combination of medical and surgical therapy. While the pathogenesis of endometriosis is still enigmatic and complex, there is increasing evidence that endometriosis is part of a uterine reproductive dysfunction syndrome. For prevention of complications, it is very important that diagnosis is made as early as possible in a woman's life.

Modelo experimental en la rata, pseudo-preñada diabetica, preimplantación y postinducción decidual (+) / Experimental model in rats with diabetic pseudopregnancy, preimplantation and decidual post induction

El estudio histológico del tejido decidual en la rata pseudopreñada, reveló una onda constante de figuras mitóticas que, partiendo de la decidua antimesometrial, se desplazó hacia la decidua mesometrial y, finalmente, hacia el triángulo mesometrial. Este y otros cambios morfológicos, como el estudio cualitativo de la superficie endometrial con microscopia eletrónica, fueron comparados con aquellos encontrados en la rata pseudopreñada diabética. No se encontraron diferencias estadísticamente significativas en cuanto a peso uterino, distribución de figuras mitóticas, ni distribución de glicógeno en los días 7 y 10 de pseudopreñez. Tampoco se observaron diferencias cualitativas entre la superficie epitelial del grupo control y diabético. El día 13, sin embargo, se encontraron tres diferencias estadísticamente significativas. Se observó en el grupo diabético: 1) caída en el peso uterino; 2) menor incidencia de figuras mitóticas en el triángulo mesometrial, y 3) menor grado de diferenciación de las arterias espirales