ABSTRACT
Objective:To study the clinical and histological features of multiple meningiomas. Methods:39 cases of multiple meningiomas were analyzed retrospectively. The expressions of PR (Progesterone receptor) , p53 and MIB-1 were detected by immunohistochemistry in the samples of multiple meningiomas and solitary meningiomas. Results:Female predominance was obvious in cases of multiple meningiomas. The tumors had wide distributions with a main location in brain convexity. The results of immunohistochemistry showed stronger expression of PR and similar expression of p53 and MIB-1 in samples of multiple meningiomas than those in solitary meningiomas. Conclusion:The diagnosis of multiple meningiomas mainly depends on radiological examination. The pathogenesis of multiple meningiomas is probably related to progesterone and its receptor, and it is most likely monoclonal origin.