ABSTRACT
To determine the frequency of various blood groups in the population of Lehtrar road Islamabad and to compare the results with national and international studies. This cross sectional observational study was conducted at Rawal Institute of Health Sciences [RIHS], from Nov 01, 2011 till Nov 30, 2012. A total of 1,739 subjects including both male and females were analyzed. Blood was collected and ABO and Rh blood groupings were carried out by standard tube method using commercially prepared antisera and frequency of ABO and RhD blood groups was determined. Among ABO blood groups the most frequent was B [33.5%], followed by O [31.3%], A [22.5%] and AB [12.41%], group respectively. Among Rh +ve cases, blood group B was the most frequent with 542 [31.1%] individuals; however among Rh -ve individuals the most frequent blood group was O [63[3.6%]]. The current study revealed that blood group B is the most frequent blood group among the ABO blood group system with dominant RhD positivity in this region
ABSTRACT
Chronic hepatitis C has a well documented association with hepatic and extra hepatic malignancies. To look into the spectrum of malignancies in chronic hepatitis C patients referred for bone marrow biopsy for having disturbances in haematological parameters. This descriptive crosssectional study was conducted at Department of Pathology, Pakistan Institute of Medical Sciences [P.I.M.S], Islamabad, from July 2009 to June 2011. A total of 90 diagnosed cases of chronic hepatitis C referred with various indications for bone marrow biopsy were included in the study. A detailed account of clinical history and physical examination was taken. All the patients were subjected to peripheral blood counts and bone marrow biopsy. Data were entered on the SPSS 14 and analyzed. Amongst a total of 90 patients, 14 [15.6%] were diagnosed to have various types of haematological malignancies. Among these seven cases were diagnosed as lympho-proliferative disorders, including 3 cases of acute lymphoblastic leukemia, 3 cases of non-Hodgkin's lymphoma and 1 case of Hodgkin's disease. Chronic myeloid leukemia was observed in 2 cases. Myelofibrosis and myelofibrosis with essential thrombocythemia and multiple myeloma were observed in 1 case each and metastatic lesion was observed in 2 cases
ABSTRACT
Haemophagocytic lymphohistiocytosis is a rare condition with over-reactive histiocytes and haemophagocytosis. It is characterized by peripheral pancytopenia, hepatosplenomegaly and repeated infections. It usually affects children but can be seen at all ages. We present a case of a five months old male child who presented with fever, pancytopenia and hepatosplenomegaly. He was referred for bone marrow examination with suspicion of leishmaniasis or any malignancy. Bone marrow aspiration did not show any atypical cells/blasts or any evidence of leishmaniasis. However there was a marked increase in histiocytes with hemophagocytosis. A diagnosis of haemophagocytic syndrome was made
ABSTRACT
Bone marrow suppression with peripheral blood cytopenias has been reported with various viral infections. Dengue fever is frequently associated with cytopenias particularly thrombocytopenia. This may be due to either bone marrow suppression or due to immunological effect. Bone marrow aplasia however may rarely be seen in patients with dengue fever and needs to be diagnosed early, as these patients have favourable outcome with immunosuppressive therapy. We present a case of a 24 years old male patient with dengue fever who manifested persistent pancytopenia. On bone marrow biopsy, he was diagnosed to have severe aplastic anemia. He was treated with immunosuppressive therapy and steroid with a favourable response.