Gestational trophobiastic diseases; a tertiary care experience

The study was carried out to evaluate the frequency and types of gestational. Trophoblastic diseases [GTD] in endometrial curettings received for histopathology examination. Data Source: Pathology Department, Shifa Naval Hospital Karachi. It was a Retrospective Descriptive Observational study. Department of Pathology, Pakistan Naval Ship; Shifa Naval Hospital Karachi. Period: From 2009 till 2010. A total of 170 cases of endometrial curettage were examined. All specimens received with a diagnosis of product of conceptions [POC] or with the clinical suspicion of a gestational trophoblastic disease were included. It was observed that partial mole identified in 57.1% cases followed by complete mole 21.4%, choriocarcinoma 14.2% and placental site Trophoblastic disease 7.1% cases. Nearly half of the cases were diagnosed as having a gestational trophoblastic disease; these were from the age groups of 26-30 years followed by 21-25 years. Hydatidiform mole is the commonest gestational trophoblastic disease, Most complete moles are detected clinically but partial moles are misdiagnosed as abortions therefore all cases of abortions should be sent for histopathological examinations

Clinicopathological aspects of malignant salivary gland neoplasms - a study of 150 cases at Afip, Rawalpindi [Pakistan]

To study the clinicopathological aspects of malignant salivary gland tumors, diagnosed at AFIP, Rawalpindi [Pakistan]. Descriptive study. Armed Forces Institute of Pathology, Rawalpindi from Jan 2005-Dec 2009. The study included all the cases diagnosed as malignant salivary gland tumors in the last five years. Records of all the tumors of head and neck region that presented during this period were analyzed and out of these clinicopathological features of malignant salivary gland tumors were studied. The data analysis included the age, gender, site of tumor and histopathological pattern. A total of 18685 malignant tumors presented in the last five years. Out of these, malignant tumors of head and neck were 2165. Total malignant salivary gland tumors were found out to be 150 with an overall frequency of 0.8% and frequency in head and neck malignancies was found out to be 6.9%. The age ranged from 6-80 years [mean 48.02 + 1.23]. Of these 150 cases, 58.7% were males and 41.3 were females with a male to female ratio of 1.4:1. The most common tumor seen was mucoepidermoid carcinoma [49.3%] followed by adenoid cystic carcinoma [31.3%]. A total of 48.7% of the tumors originated in minor salivary glands. Parotid gland was the second most commonly involved site [40.7%]. Malignant salivary gland neoplasms are a common malignancy of head and neck region and their frequency is slightly more in our population. Almost half of the tumors originated in minor salivary glands and mucoepidermoid carcinoma was the most common type of malignancy

Central nervous system tumors: a hospital based analysis

To assess the spectrum of CNS tumors and provide benchmark data for future studies assessing data in continuum. Descriptive study. This study was carried out from Jan 2003 till Jan 2009 at Pakistan Naval Ship Shifa [Naval Hospital] Karachi, Pakistan. One hundred cases fulfilling the inclusion criteria were included between the ages of 1-85 years belonging to both genders. Majority of the cases were seen in the year 2008 with the most commonly encountered lesion being the glial tumors followed by the meningiothelial neoplasms. Our findings were similar to previous similar studies in our setup with little change in trends. Glial tumors appear to be more common in our setup whereas the popularly believed Meningiothelial tumors though common came next. Our study can form the benchmark data upon which future studies can be conducted

clinico-pathological study of oral cancers

In many Asian cultures where chewing betel, paan and areca is common, oral cancer represents up to 40% of all cancers. It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomical structure. A tissue biopsy and microscopic examination of the lesion confirms the diagnosis and malignancy of oral cancer. To see the clinical and histopathological pattern of oral cancer. This was a retrospective case series studies carried out at Histopathology Department of PNS Shifa Hospital, Karachi. Detailed clinical histories of the patients were recorded and their histopathology was performed using haematoxylin and eosin [H and E] stain. Clinical data collected included the age, sex of patient and intra-oral site of cancer. Histopathological data included type of cancers and their degree of differentiation. The inference was drawn from this record. The data was analysed on SPSS version 17. A total of 268 oral mucosal biopsy reports were studied which constituted 6.6% of all malignant tumours reported during this period. Among the 268 cases studied, 256 [95.5%] cases were of squamous cell carcinoma [SCC], 4 [1.5%] were of basal cell carcinoma [BCC] and 2 [0.75%] each were of adenoid cystic carcinoma, mucoepidermoid carcinoma, adenocarcinoma and undifferentiated carcinoma. amongst the SCC group, 116 [43.28%] cases were well differentiated, 128 [47.76%] cases were moderately differentiated and 16 [5.97%] cases were poorly differentiated. Tongue was the commonest site involved in 116 [44%] cases followed by buccal mucosa 88 [33.3%] cases. Squamous cell carcinoma is the predominant type of oral cancer and tongue is the commonest site of origin for these cancers. In our patients oral cancer presented at a relatively early age group

Sebaceous carcinoma of upper eyelid

A middle aged lady was surgically treated repeatedly elsewhere for growth on right upper lid before presentation to this department. On examination she was found to have nodulo-ulcerative non-tender growth, about 40 x 20 mm in size involving the lateral three-fourth of the lid. There was associated mild conjunctivitis and palpable pre-auricular lymph node. Lid growth was excised followed by lid reconstruction. Pre-auricular lymph node was also removed. Histopathology report of the tissue revealed it to be the palpebral sebaceous carcinoma, while lymph node showed reactive hyperplasia

Pattern of female breast diseases in Karachi

The study was conducted to know the pattern of female breast diseases in Karachi. In this study there were a total of 307 breast biopsies and mastectomy specimens of which 67 were inflammatory, 166 benign and 74 malignant. Fibroadenoma was the commonest [35.179%] followed by invasive ductal carcinoma [21.824%], fibrocystic disease [16.286%], breast abscess [7.166%] and chronic mastitis [7.817%]. Fibroadenoma was common in second decade and infiltratiue ductal carcinoma in fifth decade. Breast carcinoma occurs at a younger age group in [Karachi - Pakistan] than in western countries.