ABSTRACT
Con el objetivo de disminuir la incidencia malárica en el estado Sucre, Venezuela, se practicó una cura radical masiva en 51 localidades de 6 municipios, a base de cloroquina y primaquina. Se obtuvieron coberturas de 76,5 por ciento sobre la población general y 85,7 por ciento sobre la población tratada. De un promedio de 145 casos semanales antes de la intervención, se pasó a sólo 41 después del tratamiento y el IPA disminuyó de 287 a 75 casos por 1.000 habitantes. Tomar tratamiento fue estadísticamente significante, cuando lo asociamos a la enfermedad, actuando como factor protector OR= 0,20 (I.C. 95 por ciento; 0,16 - 0,24) c2= 334,21 p<0,05
Subject(s)
Humans , Animals , Efficacy , Malaria , Treatment Outcome , Chloroquine , Malaria, FalciparumABSTRACT
The objective of this paper is to report 5 cases of rhabdomyolysis (RML) in patients with acute leukemia (AL). This occurred consecutively after the administration of chemotherapy, during the ensuing period of myelosuppression. Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias. Serum creatine kinase (CK), liver function tests and a light microscopy muscle biopsy were performed on all of them. Ten - 17 days after receiving chemotherapy, five patients (4 males and 1 female) with acute lymphoblastic leukemia developed incapacitating myalgias in neck, thighs and arms. CK and/or alanine aminotransferase and spartate aminotransferase were increased 5-24 times above the normal range in four of these patients, and the muscle byopsy showed focal RML in all five. Myalgias were self-limited and lasted 4-10 days. In addition to the chemotherapy, other factors known to be capable of producing RML, such as sepsis, other medications, and dehydration were found. In conclusion, myalgias were due to focal RML produced probably by a combination of factor, particularly the chemotherapy along with dehydration due to gastrointestinal complications, infection, and the use of diverse antibioticas. The endemic nature of the finding in such a short period of time is outstanding
Subject(s)
Humans , Male , Female , Adolescent , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Rhabdomyolysis/etiology , Rhabdomyolysis/chemically inducedABSTRACT
La perforación intestinal libre del intestino delgado en la Enfermedad de Crohn es un evento raro, la frecuencia reportada varía entre el 1 al 2 por ciento y solamente en el 25 por ciento de los casos aparece como manifestación de la enfermedad. Informamos un caso, al cual lo consideramos como único, debido al hecho de que dentro de un año hubo tres episodios independientes de perforación como manifestación única de la enfermedad
Subject(s)
Middle Aged , Humans , Female , Aminosalicylic Acids/administration & dosage , Crohn Disease/physiopathology , Intestines/surgery , Intestinal Obstruction/complications , Intestinal Perforation/physiopathology , Surgical Procedures, Operative/statistics & numerical dataABSTRACT
Informamos un caso de carcinoma escamoso primario de hígado en un paciente masculino de 38 años de edad. Se realizó una revición de la literatura mundial encontrando únicamente 12 casos reportados y todos ellos en pacientes masculinos; no encontramos reportes de este tumor en la literatura mexicana. El pronóstico de estas lesiones es malo y la sobrevida promedio no es mayor de seis meses