ABSTRACT
BACKGROUND: The aging of skin is influenced by genetic, environmental, and hormonal factors. Estrogens are the "missing" player in the skin of postmenopausal women. In postmenopausal women, loss of collagen was related to decreased estrogen level. Phytoestrogens, i.e. isoflavone, are plant compounds with estrogen-like biologic activities. OBJECTIVE: The effects of 18beta-estradiol, and isoflavones on production of type I collagen in the fibroblast of postmenopausal woman, keloid and Detroit cell line were examined. METHODS: Type I collagen was measured with procollagen type I C-peptide EIA KIT. RESULTS: 18beta-estradiol and isoflavone enhanced the production of type I collagen in cultured fibroblast of postmenopausal woman and keloid. But isoflavone inhibited the production of collagen in cultured fibroblast of Detroit cell. CONCLUSION: 18beta-estradiol and isoflavone can prevent and improve the cutaneous alterations caused by loss of collagen of postmenopausal women.
Subject(s)
Female , Humans , Aging , C-Peptide , Cell Line , Collagen Type I , Collagen , Estradiol , Estrogens , Fibroblasts , Isoflavones , Keloid , Phytoestrogens , Plants , SkinABSTRACT
BACKGROUND: Mohs surgery is an increasingly appealing option for skin cancer. It is traditionally performed by a Mohs dermatologist, followed by a secondary repair by a head and neck or plastic surgeon. But one-stage procedure Mohs surgery with immediate reconstruction enhances patient's satisfaction and reduces the need for more than one procedure or multiple postoperative visits. OBJECT: The purpose of this study was to report our experience of Mohs surgery and immediate reconstruction by a dermatologist. Results, complications, and recurrence rates were reviewed. METHODS: Seventy five skin cancers, which were treated by Mohs surgery and reconstructed immediately were analysed retrospectively. RESULT: There were 43 females and 32 males. The mean age was 62.2. Basal cell carcinoma was the most common skin tumor. The Nose was the most common anatomic site. The mean size of tumor was 1.8cm. The local flap was the most common used to repair surgical defects. Complications were minimal. Recurrent cases were none during 40-months follow up (range, 12-58 months). CONCLUSION: Immediate one-stage reconstruction after Mohs surgery by a dermatologist is a safe, convenient method to treat skin cancers.
Subject(s)
Female , Humans , Male , Carcinoma, Basal Cell , Follow-Up Studies , Head , Mohs Surgery , Neck , Nose , Recurrence , Retrospective Studies , Skin Neoplasms , SkinABSTRACT
Superficial dermatophytic infections are considered to be mild superficial epidermal infection. Most organisms are located superficially in stratum corneum. Sometimes, they may involve the hair follicles, producing papule, pustule, or nodule, characterized clinically as kerion. It usually occurs on scalp or beard area but may occur elsewhere on the body. We report a case of kerion on glabrous skin. The patient presented with intense, boggy mass with suppurations on left thigh. On mycologic examination, Trichophyton verrucosum was isolated. We report this atypical form of localized inflammatory infection caused by tinea.
Subject(s)
Humans , Hair Follicle , Scalp , Skin , Thigh , Tinea , TrichophytonABSTRACT
Superficial dermatophytic infections are considered to be mild superficial epidermal infection. Most organisms are located superficially in stratum corneum. Sometimes, they may involve the hair follicles, producing papule, pustule, or nodule, characterized clinically as kerion. It usually occurs on scalp or beard area but may occur elsewhere on the body. We report a case of kerion on glabrous skin. The patient presented with intense, boggy mass with suppurations on left thigh. On mycologic examination, Trichophyton verrucosum was isolated. We report this atypical form of localized inflammatory infection caused by tinea.