The Role of TNFalpha Gene Promoter Polymorphism in the Development of Coal Workers' Pneumoconiosis / 대한산업의학회지

OBJECTIVES: This study was performed in order to investigate the frequency of the TNF2 allele in patients with coal workers pneumoconiosis (CWP). METHODS: We compared the genotype distribution of TNFalpha gene promoter polymorphism between 80 CWP patients and 54 healthy controls. RESULTS: The results were as follows : 1. The rare allele TNF2 was significantly more frequent in CWP patients (20.6 %) than in controls (10.2 %). 2. The spontaneous or LPS-induced release of TNFalpha from the peripheral monocytes was slightly increased in the TNF2 group, but these values were not significantly different between groups. 3. In the CWP TNF2 group, the increase of LPS-induced TNFalpha release was significant in comparison with that of the controls. CONCLUSIONS: From the above results, we suggest that the TNF2 allele is strongly associated with susceptibility to CWP development.

Activity of Telomerase in Coal Worker's Autopsied Lung / 대한산업의학회지

OBJECT: We measured the activity of telomerase in coal workers lung tissue and found a significant increase in telomerase activity compared to the control group. Pneumoconiosis has the characteristics of fibroblast proliferation and the accumulation of collagen,thus finally causing the pathologic changes,which lead to the irreversible and progressive fibrosis of the lungs. We hypothesized that this cellular proliferation causing irreversible fibrosis may induce some elongation of the life cycle in the chromosomes and lead to further cellular immortalization. METHOD: 8 postmortem(within 24 hours)pneumo-coniotic cases were examined and their telomerase activity was compared with that of the autopsied lungs of lung cancer patients and of accident victims without any respiratory diseases. Using the extracted ribo-nucleoprotein from pneumoconiotic nodules, telomeric repeat amplification assay (TRAP)was done. RESULT: The pneumoconiotic lungs showed strong telomerase activity, similar to that of the lung cancer patients, while the control group showed no such activity. CONCLUSION: Based on the results of this study, we found that coal dust-induced cellular proliferation affects telomerase-activity clinically.

An Unusual Form of Progressive Massive Fibrosis In Pneumoconiosis / 결핵

Pneumoconiosis, very popular to coal miners who are exposed to coal dusts dominantly, was introduced in the 19th century to describe lung diseases consequent to the inhalation of mineral dusts. Coal workers' pneumoconiosis(CWP) colloquially called "black lung" in the United States, is a distinct pathologic entity resulting from the tissue reaction to deposits of dust include the coal macule, which associated with focal emphysema constitutes the characteristic lesion of simple CWP and complicated CWP or progressive massive fibrosis(PMF). Coal mining are also associated with chronic bronchitis, chronic airflow limitation, and/or generalized emphysema. Progressive massive fibrosis lesions may imprint on and obliterate airways and vessels, and cavitation is not uncommon, being the consequence of ischemic necrosis or mycobacterial infections. We report a case which is unusual form of progressive massive fibrosis to be differentiated from lung carcinoma. It is a rapid growing PMF with ischemic necrosis. By the studies which are about risk of having progressive massive fibrosis, it is predicted to be 1.4%. And the other study shows that simple pneumoconiosis clearly predisposed to PMF, with five year attack rates of 13.9%, 12.5%, 4.4% and 0.2% among men with categories 3, 2, 1, and 0 respectively at the start of the risk periods.

Normative Data of Grip and Pinch Strength for Screening of Cumulative Trauma Disorders / 대한산업의학회지

Executing detailed examination for cumulative trauma disorders(CTD) for all the workers with repetitive operators is not desirable considering the cost-effectiveness. Screening test with subjective symptoms, physical examination and hand strength test to detect the proper subject for secondary detailed examination is needed. The purpose of this study was to determine normal values for grip and pinch(tip, lateral and palmar) strength to be used as a screening tool for CTD. Total of 1,018 healthy subjects without related past occupational or medical history were examined with Jamar dynamometer and pinch gage. Each hand was checked twice in a posture recommended by American Society of Hand Therapists, and higher value was accepted. The results were as follows, 1. The mean grip strength of right hand in right-handed man was 47.7 kg, and 27.2 kg in woman. The mean tip pinch strength of right hand in right-handed man was 6.2 kg, and 3.9 kg in woman. The mean lateral pinch strength was 9.0 kg in man, and 5.5 kg in woman. And the mean palmar pinch strength was 9.3 kg in man, and 6.9 kg in woman. There was no significant differences in dominant hand power according to the right or the left hand dominances. 2. Selecting 10 percentile value for screening criteria for CTD, 10 percentile value of trip strength was 38 kg in man and 20 kg in woman. And that of tip pinch strength was 4 kg in man and 2 kg in woman, lateral pinch strength was 6 kg and 4 kg each, palmar pinch strength was 6 kg and 5 kg each. 3. Grip and all three pinch strengths of man showed positive correlation with age, height and weight, but in the cases of woman, only grip strength showed positive correlation with height and weight. 4. In cases of right-handed persons, dominant hand showed higher grip strength compared to the contralateral hand in 70.9% of males, and 72.9% of females. And the mean differences of bilateral grip strength was 2.7 kg(5.2%) in male, and 1.7 kg(5.7%) in female. But in the cases of left-handed persons, dominant hand did not show the significant difference in strength compared to the contralateral hand.