ABSTRACT
A 42-year-old woman was treated with total abdominal hysterectomy and bilateral salpingo- oophorectomy due to endometrial carcinoma 3 years ago, and has taken regular check-ups ever since. A 1.0cm-sized, yellow-orange colored, pedunculated mass had ben developed on her scalp about 1 year before. Excision showed an exophytic pedunculated, well-circumscribed nodule composed of predominant undifferentiated basaloid cells, some vacuolated sebocytes and numerous sebaceous duct like structures. There was no relapse during the follow-up of about 6 months. The development of sebaceous epithelioma in this case would be associated with Muir-Torre syndrome.
Subject(s)
Adult , Female , Humans , Carcinoma , Endometrial Neoplasms , Follow-Up Studies , Hysterectomy , Muir-Torre Syndrome , Ovariectomy , Recurrence , ScalpABSTRACT
A 66-year-old woman presented with a 1.5 by 1.2 cm sized, crusted erythematous nodule on the lateral aspect of her left calf. She had a small nodule on the left calf that had been removed by electrocauterization before her visit, but which had recurred. There was no previous history of trauma to the area. Histopathologic diagnosis was consistent with eccrine poroma. The tumor was excised, and no recurrence was noted when she examined 8 months later. We report a case of eccrine poroma arising on the left calf where is unusual location.
Subject(s)
Aged , Female , Humans , Diagnosis , Poroma , RecurrenceABSTRACT
The clematis apiifolia A.P. DC. is a plant which belongs to Clematis Linne, Ranunculaceae. It contains anemonol, clematiscampher, clematin, labenzyme, saponin, of which anemonol is a probable irritant reacting component. We report two cases of irritant dermatitis due to Clematis apiifolia A.P.DC. plant. These patients developed painful, inflamed erythematous patches with flaccid bullae and erosions on the application sites of the crushed plant for self-treatment of arthralgia.
Subject(s)
Humans , Arthralgia , Clematis , Dermatitis, Irritant , Plants , Ranunculaceae , SaponinsABSTRACT
Photodynamic therapy(PDT) is a treatment modality by highly reactive oxygen intermediates generated through the interaction of light with a photosensiziter. It has been shown to be an effective treatment for various cutaneous and noncutaneous malignancies. It is efficient for the curative and palliative treatment of epithelial skin tumor in situ or early invasive lesions. In effect, it is a useful alternative treatment for the lesions located on anatomically difficult areas or the large-sized lesions. We treated a case of Bowen's disease arising on the plantar area and 3rd and 4th toewebs of left forefoot in a 61-year-old man with PDT using the hematoporphyrin derivative, porfirmer sodium(Photofrin, Russia) as a photosensitizer and gold vapor laser as a visible light source. The outcome showed partial clinical improvement after about 2 months' follow-up.
Subject(s)
Humans , Middle Aged , Bowen's Disease , Follow-Up Studies , Hematoporphyrin Derivative , Lasers, Gas , Light , Oxygen , Palliative Care , Photochemotherapy , SkinABSTRACT
Nodular fasciitis is an uncommon nonneoplastic swelling consisting of reactive fibroblastic proliferation occurring in the subcutaneous tissue of the extremities. It is characterized by benign clinical course and aggressive histologic features mimicking soft tissue sarcoma, Herein we report a 33-year-old man with a solitary, tender, 1.2 X 1.5cm sized hard nodule on the right forearm which clinically and histologically shows a typical nodular fasciitis.
Subject(s)
Adult , Humans , Extremities , Fasciitis , Fibroblasts , Forearm , Sarcoma , Subcutaneous TissueABSTRACT
Incontinentia pigmenti is an uncommon genodermatosis presented by characteristic cutaneous stages and frequent association with one or more ectodermal or mesodermal anomalies. A new-born girl, 2 days old, had had crops of erythematous papules and vesicles on the trunk and extremities. At 2 years of age, she had the whorled hyperpigmentation. There were no anomalous features in teeth, eyes and hair, but she had a neurologic disorder. Left hemiplegia, related to upper motor neuron weakness, showed brisk left DTR, spastic Achilles tendon with walking disorders, decreased grasping power of left hand and weakness of left upper extremity. Brain MRI revealed marked loss of volume in the white matter of the right lateral ventricle in T1 weighted images. We report herein an explicit case of incontinentia pigmenti associated with right cerebral hemiatrophy.
Subject(s)
Female , Humans , Achilles Tendon , Brain , Ectoderm , Extremities , Hair , Hand , Hand Strength , Hemiplegia , Hyperpigmentation , Incontinentia Pigmenti , Lateral Ventricles , Magnetic Resonance Imaging , Mesoderm , Motor Neurons , Muscle Spasticity , Nervous System Diseases , Tooth , Upper Extremity , WalkingABSTRACT
We describe a 16-year-old female with Nevus comedonicus(NC) that has been developed since birth. The lesions had a unilateral, linear or zosteriform distribution on the left lower leg and posterior thigh, and were well closely arranged, slightly depressed papules that had dark firm plugs resembling comedones in their centers. In the meantime, recurrent infections with fistula, abscess and residual scars had been complicated. Histopathologic features showed deep invagination of epidermis and dilated follicular orifices filled with keratin plugs in the centers of papules.
Subject(s)
Adolescent , Female , Humans , Abscess , Cicatrix , Epidermis , Fistula , Leg , Lower Extremity , Nevus , Parturition , ThighABSTRACT
Herpes Zoster duplex -zoster affecting 2 separate dermatome simultaneously- is a rare disease. A 65 year old man, healthy in the past, presented with severely painful grouped papulovesicles and hemorrhagic crusts on the erythematous base on the right forehead and nasal bridge(V-I dermatome) and left chest(T4 dermatome) with nearly simultaneous occurrence. Tzanck smear revealed multinucleated giant cells and biopsy taken from the chest lesion showed the features consistent with herpetic viral blister. He was treated with intravenous administration of acyclovir for 5 days and both lesions were markedly improved.
Subject(s)
Aged , Humans , Acyclovir , Administration, Intravenous , Biopsy , Blister , Forehead , Giant Cells , Herpes Zoster , Rare Diseases , ThoraxABSTRACT
Atypical fibroxanthoma(AFX) is a pleomorphic spindle cell neoplasm of the dermis, which is a clinically benign reactive lesion despite apparently malignant histologic features. We describe a 38-year-old woman with AFX developed on the right popliteal area. The lesion was superficially located and composed of densely cellular, pleomorphic spindle cells and several bizarre multinucleated giant cells. It is uncommon that AFX developes on the lower leg in the middle age.
Subject(s)
Adult , Female , Humans , Middle Aged , Dermis , Giant Cells , LegABSTRACT
A rare case of perforating pilomatricoma is reported. A rice grain-sized lesion occurred on the 23-year-old man's left upper arm about 3 years ago. It has developed into a 0.5X0.8cm sized well-defined scaly hard tumor during recent 1 year. Excised tumor showed small islands of shadow cells in the mid-dermis and calcified materials, extruded from the dermis into the deeply invaginated epidermis, by transepidermal elimination.
Subject(s)
Humans , Young Adult , Arm , Dermis , Epidermis , Islands , PilomatrixomaABSTRACT
A rare case of perforating pilomatricoma is reported. A rice grain-sized lesion occurred on the 23-year-old man's left upper arm about 3 years ago. It has developed into a 0.5X0.8cm sized well-defined scaly hard tumor during recent 1 year. Excised tumor showed small islands of shadow cells in the mid-dermis and calcified materials, extruded from the dermis into the deeply invaginated epidermis, by transepidermal elimination.
Subject(s)
Humans , Young Adult , Arm , Dermis , Epidermis , Islands , PilomatrixomaABSTRACT
Leprosy is a granulomatous disease primarily affecting the peripheral nerves. The pathogenesis would be related to the cell-mediated response to mycobacterial antigens, metabolic and biochemical change of Schwann cell, circulating demyelinating factors and other autoimmune process. A specific nerve tissue protein, S-100 protein, has been demonstrated in normal nerves and nerve complexes. The stains of S-100 protein in dermal nerves of leprosy patients have been suggested in assessing the presence of nerve damage. We have estimated the concentration of S-100 protein in the sera of 64 leprosy patients(38 lepromatous leprosy, 26 tuberculoid leprosy) and that of 20 normal controls without neurologic disorders by ELISA. The results obtained were as follows: 1. The mean S-100 protein concentration was 0.0042ng/ml in a total of 64 leprosy patients, with 0.0062ng/ml in lepromatous type and 0.018ng/ml in tuberculoid type. The controls showed 0.0017ng/ml. 2. The analysis of age and serum S-100 protein concentration in both types showed lower value in the fifties of tuberculoid type(p0.05). 3. The analysis of duration of illness and serum S-100 protein concentration in both types showed higher value in the forties and fifties in lepromatous type(p0.05). 4. The mean S-100 protein concentration of patients with neurologic symptoms was 0.0577ng/ml, in contrast with 0.0016ng/ml in patients without neurologic symptoms (p<0.05). In conclusion, the measurement of serum S-100 protein would play a potential role of a useful marker of assessing nerve damage in leprosy patients, esp, with neurologic symptoms.
Subject(s)
Humans , Coloring Agents , Enzyme-Linked Immunosorbent Assay , Leprosy , Leprosy, Lepromatous , Nerve Tissue , Nervous System Diseases , Neurologic Manifestations , Peripheral Nerves , S100 ProteinsABSTRACT
Progressive pigmented purpura(Schamberg type) is of uncertain etiology. The lesion is characterized by a symmetrical rash of petechial and brown pigmented macules limited to the legs. Unilateral occurrence is considered a rarity. We report a 37-year-old woman presented with a 20-year history of unilateral distribution of purpuric and pigmented lesions scattered on the right shin and calf. Histopathologic feature showed band-like infilterate of superficial perivascular lymphohistiocytes with extravasation of erythrocytes and hemosiderin deposition in the upper dermis.
Subject(s)
Adult , Female , Humans , Dermis , Erythrocytes , Exanthema , Hemosiderin , Leg , PurpuraABSTRACT
The true neuromas represent a specific entity in the range of benign nerve sheath tumor. The lesions exist in the skin and mucous membrane. Of these, palisaded encapsulated neuroma(PEN) is a solitary tumor measuring less than 0.5 cm and usually locates on the face. A 5-year-old boy presented with an isolated 3.0X3.0X0.7cm sized, soft collagenoma-like mass on the plantar area of left foot. It had developed for about 4 years. The histologic features demonstrated PEN-like encapsulated bulbous expansions in the dermis. This clinical manifestation of neuroma is considered a rarity.
Subject(s)
Child, Preschool , Humans , Male , Dermis , Foot , Mucous Membrane , Neuroma , SkinABSTRACT
We report an unusual case of necrobiosis lipoidica with prominent cholesterol clefts in a 36-year-old man who had developed multiple, 0.5~5cm in diameter, round to oval-shaped erythematous plaques on both shins for over 3 years. Laboratory findings showed the following; cholesterol, 250mg/dl; triglyceride, 208mg/dl; blood sugar level fasting/2-h postprandial, 101/92mg/dl; and other findings were within normal limits or negative. There was no paraproteinemia. The biopsy specimen showed various lymphohistiocytic granuloma with many giants cell in the mid and deep dermis, and septal fibrosis in the subcutaneous tissue. There were also extensive areas of necrobiosis with prominent cholesterol clefts mimicking necrobiotic xanthogranuloma.