ABSTRACT
Gitelman syndrome is an autosomal recessive hereditary disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, salt wasting, low blood pressure, and hypocalciuria. Gitelman's syndrome is generally considered to be benign, and muscle weakness may be the only manifestation of hypokalemia. To our knowledge, there have been no case reports of rhabdomyolysis due to severe hypokalemia of Gitelman's syndrome in Korea. We report a case of Gitelman's like syndrome presenting with paralysis of both lower extrimities and myalgia. Rhabdomyolysis caused by severe hypokalemia was diagnosed and recovered with supportive therapy, including the administration of 0.9% normal saline and KCl.
Subject(s)
Alkalosis , Gitelman Syndrome , Hypokalemia , Hypotension , Korea , Muscle Weakness , Myalgia , Paralysis , RhabdomyolysisABSTRACT
We describe a case of congenital nephrogenic diabetes insipidus with severe dilatation of bilateral urinary tracts without anatomical obstructions. Functional obstruction can be occurred when polyuria surpasses the transporting ability of urine in the urinary tract. The patient was admitted to our hospital due to decreased mentality developed after traffic accident. On radiologic study, bilateral hydronephrosis and hydroureter were noted. Because the patient excreted copious dilute urine, we performed water deprivation test and the result was consistent with nephrogenic diabetes insipidus. We are presenting this case in an attempt to describe strong association between congenital diabetes insipidus and nonobstructive hydronephrosis in which polyuria is responsible for the hydronephrosis.
Subject(s)
Humans , Accidents, Traffic , Diabetes Insipidus , Diabetes Insipidus, Nephrogenic , Dilatation , Hydronephrosis , Polyuria , Urinary Tract , Water DeprivationABSTRACT
Central pontine myelinolysis (CPM) is a rare syndrome, especially in uremic patients undergoing dialysis. CPM induced by diabetic coma in hemodialysis patients or associated with rapid correction of hyponatremia in peritoneal dialysis patients have been reported. However, its pathogenesis has been unclear. We report a case of CPM in a 67-year-old female uremic patient undergoing continuous ambulatory peritoneal dialysis, who was admitted to our hospital for drowsy mentality. Sodium was normal (140 mEq/L) initially and throughout the entire clinical course. The fasting blood sugar level was 110 mg/dL, serum osmolality 312 mOsm/KgH2O and osmolar gap 9.47. The axial T2-weighted brain MRI showed high signal intensity in the basal pons.
Subject(s)
Aged , Female , Humans , Blood Glucose , Brain , Diabetic Coma , Dialysis , Fasting , Hyponatremia , Magnetic Resonance Imaging , Myelinolysis, Central Pontine , Osmolar Concentration , Peritoneal Dialysis , Peritoneal Dialysis, Continuous Ambulatory , Pons , Renal Dialysis , SodiumABSTRACT
BACKGROUND & METHODS: Approximately 10% of the essential hypertensive patient have overt proteinuria due to renal target organ damage, which indicates poor prognosis. Recently microalbuminuria has been prove to be a good early predictor for renal damage in patients with diabetes or hypertension. Some authors reported that near 40% of the essential hypertensives have microalbuminuria. To determinate prevalence of microalbuminuria in Korea essential hypertensives, 24-hr ambulatory blood pressure monitoring and radioimmunoassay to detect BP and UAER were performed after 4 weeks wash-out period in 137(78 hypertensive and 54 normotensive) consecutive cases. RESULTS: Among 78 hypertensives, overt proteinuria was seen in 8.97%(7/78). And prevalence of microalbuminuria were 29.4%(23/78) in hypertensives and 16.7%(9/54) in normotensives. Urine microalbumin excretion rate(UAER) was significantly correlated with mean arterial pressure(MAP) in total subjects(r=0.286, p=0.0012), but not in total hypertensives(r=0.135, p=NS) or in hypertensives with UAER(r=-0.098, p=NS).UAER of female hypertensives was increase than that of male hypertensives(13.17+/-16.28microg/min vs 22.87microg/min, p=0.027). CONCLUSION: Prevalence of microalbuminuria in Korean hypertensives was relatively lower then other reports. Overt proteinuria was noted in 8.97% of the hypertensives which is same prevalence as other countries. Moreover MAP was well correlated with UAER in total subjects. Further evaluation should be done to detect exact role of UAER in hypertensives as an early predictor for renal target organ damage.
Subject(s)
Female , Humans , Male , Blood Pressure Monitoring, Ambulatory , Blood Pressure , Hypertension , Korea , Prevalence , Prognosis , Proteinuria , RadioimmunoassayABSTRACT
BACKGROUND & METHODS: Approximately 10% of the essential hypertensive patient have overt proteinuria due to renal target organ damage, which indicates poor prognosis. Recently microalbuminuria has been prove to be a good early predictor for renal damage in patients with diabetes or hypertension. Some authors reported that near 40% of the essential hypertensives have microalbuminuria. To determinate prevalence of microalbuminuria in Korea essential hypertensives, 24-hr ambulatory blood pressure monitoring and radioimmunoassay to detect BP and UAER were performed after 4 weeks wash-out period in 137(78 hypertensive and 54 normotensive) consecutive cases. RESULTS: Among 78 hypertensives, overt proteinuria was seen in 8.97%(7/78). And prevalence of microalbuminuria were 29.4%(23/78) in hypertensives and 16.7%(9/54) in normotensives. Urine microalbumin excretion rate(UAER) was significantly correlated with mean arterial pressure(MAP) in total subjects(r=0.286, p=0.0012), but not in total hypertensives(r=0.135, p=NS) or in hypertensives with UAER(r=-0.098, p=NS).UAER of female hypertensives was increase than that of male hypertensives(13.17+/-16.28microg/min vs 22.87microg/min, p=0.027). CONCLUSION: Prevalence of microalbuminuria in Korean hypertensives was relatively lower then other reports. Overt proteinuria was noted in 8.97% of the hypertensives which is same prevalence as other countries. Moreover MAP was well correlated with UAER in total subjects. Further evaluation should be done to detect exact role of UAER in hypertensives as an early predictor for renal target organ damage.
Subject(s)
Female , Humans , Male , Blood Pressure Monitoring, Ambulatory , Blood Pressure , Hypertension , Korea , Prevalence , Prognosis , Proteinuria , RadioimmunoassayABSTRACT
No abstract available.
Subject(s)
Arachnoid , Arachnoiditis , Magnetic Resonance Imaging , TuberculosisABSTRACT
No abstract available.
Subject(s)
Arachnoid , Arachnoiditis , Magnetic Resonance Imaging , TuberculosisABSTRACT
No abstract available.