Short term evaluation of stanazolol in acquired idiopathic aplastic anemia

Eleven cases of acquired idiopathic aplastic anemia were treated with Stanozolol and six cases with methyltestosterone to determine whether anabolic steroids, when used singly, are effective in the treatment of this disorder, and whether analogues with minimal androgenic properties would stimulate hemopoiesis as well. Our data suggest that Stanozolol stimulated hemoglobin and reticulocyte rise within three months of treatment or as early as four to six weeks and decreased the transfusion requirements in these cases as well as methyltestosterone without the undesirable masculinization of the subjects. It is apparent that the erythropoietic stimulation of testosterone resides primarily in the anabolic principle and is not lost with decreasing androgenicity. The neutrophile and platelet response was rather slow. The platelets in particular failed to normalize even in those where the hemoglobin levels have reached normal proportions. However, the subjects became free from serious bleeding. Infection was not a serious problem in our series. Only one of the seventeen cases died within the period of observation. Only two individuals had neutrophile counts below 1000 per cubic mm. initially, both of whom survived pulmonary and gastrointestinal infections. (Summary)

Clinical aspects, laboratory manifestation and serologic studies of a newly observed arbor a virus infection

18 cases of Chikungunya (or a very closely related virus) infection, a newly observed clinical entity in the Philippines, are presented. Diagnosis was established by serological studies consisting of hemagglutination-inhibition (HI) and complement fixation (CF) tests. (Summary)