ABSTRACT
Circular RNAs (circRNAs) are a class of non-coding RNAs that form closed rings in structure. They contain a high content in eukaryotic transcripts, and are characterized by richness, stability, high conservatism and tissue specificity. In recent years, it has been gradually revealed that circRNA can bind to some miRNAs or proteins and participate in the regulatory mechanisms of biogenesis and molecular functions, including the regulation of miRNAs molecular sponge, protein translation, gene transcription and RNA splicing. With the application of high-throughput sequencing and bioinformatics, circRNA has gradually become a new research hotspot in the field of non-coding RNA due to its special properties. The latest research evidence shows that circRNA plays a key role in the occurrence and development of tumors, and is inextricably linked with cell proliferation, apoptosis, angiogenesis, and metastasis, indicating that targeting circRNA will be attractive treatment strategies and potential biomarkers. In this paper, the characteristics and mechanism of circRNA were briefly described, the mechanism of action and regulation of circRNAs in human tumors were summarized, and the strategies and development prospects of circRNA in tumor research were further discussed. In sum, circRNA plays an important role in early diagnosis, precise treatment and prognosis prediction of tumors.
ABSTRACT
Objective Through analyzing the literatures about acupuncture-moxibustion in releasing chemotherapyinduced nausea and vomit,to understand its current situation and progress,preparing for further studies in the future.Method Four databanks were retrieved.Two researchers independently skimmed the titles and abstracts for filtering the collected data,and then carefully read through the full texts for further selection.Snowball retrieval of the references in each recruited article completed the whole literature search.Result A total of 407 manuscripts were collected by retrieving databanks,but 80 were excluded due to ineligible designs or intervention protocols.Finally,76 articles were included.Conclusion Acupuncture-moxibustion is effective in preventing and treating nausea and vomit induced by chemotherapy.Future studies should rigorously follow the randomized controlled trials design and adopt precise efficacy evaluations,to provide foundation for subsequent evidence-based studies.