ABSTRACT
Abstract The etiological diagnosis of orbital myositis (OM) is a challenge. Although it has been associated with previous infectious disease, diseases with autoimmune background, thyroidopathies or with paraneoplasic syndrome, most of them still remain as idiopathic. We describe here a case of OM uncovering a Behçet disease that is considered a rare cause for this kind of eye involvement.
Resumo Trata-se de um caso de ceratite bilateral e simultânea por Acremonium relacionada ao uso intermitente e sem respeitar a lateralidade O diagnóstico etiológico da miosite orbitária (MO) é desafiador. Embora ela tenha sido relacionada com doenças infecciosas prévias, doenças associadas à autoimunidade, tireoidopatias ou síndromes para neoplásicas, a maioria delas ainda permanece como idiopática. Descreve-se aqui, um caso de MO revelando o diagnóstico de doença de Behçet, doença considerada como uma causa pouco comum para este tipo de envolvimento ocular.
Subject(s)
Humans , Female , Adult , Behcet Syndrome/complications , Behcet Syndrome/diagnosis , Orbital Myositis/diagnosis , Orbital Myositis/etiology , Ophthalmoscopy , Azathioprine/therapeutic use , Biopsy , Prednisone/therapeutic use , Magnetic Resonance Imaging , Esotropia , Botulinum Toxins, Type A/therapeutic use , Orbital Myositis/drug therapy , Visual Field Tests , Infliximab/therapeutic use , Oculomotor Muscles/pathologyABSTRACT
ABSTRACT Background Rheumatic diseases such as ankylosing spondylitis (AS) may be associated with sexual dysfunction. Aim To study erectile function of a group of Brazilian AS patients comparing them with controls. Materials and Methods This was a cross sectional study approved by the local Committee of Ethics in Research. The questionnaire IIEF (International Index of Erectile Function) was applied to 40 AS patients and 40 healthy controls. AS patients had determination of disease activity (through BASDAI or Bath Ankylosing Spondylitis Disease activity index), ASDAS (Ankylosing Spondylitis Disease Activity Score, MASES or Maastricht Ankylosing Spondylitis Score and SPARCC or Spondyloarthritis Research Consortium of Canada), function (through BASFI or Bath Ankylosing Spondylitis Functional Index and HAQ or Health Assessment Questionnaire) and BASMI (Bath Ankylosing Spondylitis Metrological Index). Results AS patients had a median score on IIEF of 22.0 (IQR=18-25) while controls had 29 (IQR=27-30) with p<0.0001 Only 17.5% of the AS patients had no erectile dysfunction, in opposite to 87.5% of controls (p<0.0001). IIEF scores had a negative association with BASDAI (p<0.0001), HAQ (p=0.05), body mass index (P=0.03), MASES (P=0.02) and SPARCC (P=0.02) in a univariate analysis. Multiple regression showed that BASDAI was the only variable independently associated with IIEF. Conclusion There is a high prevalence of erectile dysfunction among AS patients that is associated with disease activity measured by BASDAI.
Subject(s)
Humans , Male , Adult , Spondylitis, Ankylosing/complications , Erectile Dysfunction/etiology , Case-Control Studies , Cross-Sectional Studies , Surveys and Questionnaires , Erectile Dysfunction/epidemiology , Middle AgedABSTRACT
Objetivo: Estudar se os níveis de vitamina D influem na atividade das espondiloartrites. Métodos: Estudo transversal observacional de 92 pacientes com ES e 92 controles para níveis de vitamina D. Níveis de vitamina D foram associados com perfil clinico e laboratorial e com dados de atividade da doença medidos pelo BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) e dados de função medidos pelo BASFI (Bath Ankylosing Spondylitis Disease Functional Index). Resultados: Os níveis de vitamina D dos controles eram semelhantes ao dos indivíduos normais (p=0.36). Encontrou-se associação dos níveis de vitamina D com BASDAI (p= 0,01) e com os valores de hemoglobina (p=0,04) dos pacientes. Nenhum dos demais parâmetros estudados associou-se com níveis de vitamina D. Conclusão: Níveis séricos de vitamina D estão associados com maior atividade de doença em pacientes com espondiloartrites.
Objective: To study whether vitamin D levels influence the activity of spondyloarthritis. Methods: This is an observational cross-sectional study of 92 patients with SpAand 92 controls for vitamin D. Vitamin D serum levels were associated with clinical and laboratory profile as well as activity data of the disease measured by the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and functional data measured by BASFI (Bath Ankylosing Spondylitis Disease Functional Index). Results: Vitamin D levels of controls were similar to that of normal subjects (p = 0.36). Vitamin D levels associated with BASDAI (p = 0.01) and hemoglobin values (p = 0.04) of patients. None of the other studied parameters related with levels of vitamin D. Conclusion: Serum vitamin D levels are associated with increased disease activity in patients with SpA.