ABSTRACT
OBJECTIVE: To identify main symptoms and signs on computerized vestibular testing in patients diagnosed with multiple sclerosis. METHOD: Thirty patients with the diagnosis of multiple sclerosis were studied. We analyzed data related to presented symptoms and the findings from a computerized vestibular testing realized in the otoneurological ambulatory in Santa Casa de Misericórdia de São Paulo in 2003. RESULTS: Reported symptoms consisted mainly of disequilibrium (60%), tingling of limbs (43.3%), vertigo (40%), headache and anxiety (36.7%), tinnitus (30%), depression (26.7%). In vestibular testing we found alterations in positional nystagmus (6.7%), spontaneous nystagmus with the eyes shut (30%), directional nystagmus (13.3%) and caloric testing (63.3%). In the final conclusion of the exam, the diagnosis of irritative type peripheral vestibular syndrome (60%) and central syndrome (13.4%) prevailed. CONCLUSION: We conclude that the realization of an otoneurological exam has become indispensable in patients with multiple sclerosis. This is due to high prevalence of alterations at computerized vestibular exam and of otoneurological symptoms.
OBJETIVO: Descrever os principais sintomas e sinais ao exame vestibular computadorizado em pacientes com diagnóstico de esclerose múltipla. MÉTODO:Foram examinados 30 pacientes com diagnóstico de esclerose múltipla. Analisaram-se os dados relativos à sintomatologia e achados ao exame vestibular computadorizado realizado no ambulatório de otoneurologia da Irmandade Santa Casa de Misericórdia de São Paulo, em 2003. RESULTADOS: Em relação aos sintomas relatados, observamos desequilíbrio (60%), formigamento de extremidades (43,3%), vertigem (40%), cefaléia e ansiedade (36,7%), zumbido (30%), depressão (26,7%). Ao exame vestibular encontramos alterações do nistagmo de posicionamento (6,7%), nistagmo espontâneo de olhos fechados (30%), nistagmo semi-espontâneo (13,3%), rastreio pendular (3,3%) e prova calórica (63,3%). Na conclusão do exame tivemos prevalência de síndrome vestibular periférica irritativa (60%) e síndrome central (13,4%). CONCLUSÃO: Concluimos que a realização do exame otoneurológico torna-se imprescindível nos pacientes com esclerose múltipla devido a elevada prevalência de alterações à vectonistagmografia computadorizada e elevada prevalência de sintomas otoneurológicos.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Diagnosis, Computer-Assisted/methods , Multiple Sclerosis/complications , Vestibular Function Tests/methods , Electronystagmography/methods , Nystagmus, Pathologic/diagnosis , Nystagmus, Pathologic/etiology , Paresthesia/diagnosis , Paresthesia/etiology , Dizziness/diagnosis , Dizziness/etiology , Vertigo/diagnosis , Vertigo/etiologyABSTRACT
The bacteriological and clinical efficacy and the safety of gatifloxacin for the treatment of non-complicated acute rhinosinusitis was evaluated in 49 adult patients in an open-label multicenter study in Brazil. Patients under age 18, or with associated systemic diseases, were excluded. Diagnosis was based on symptoms, otorhinolaryngological examination, and X-rays of the sinus. At the first visit, all patients were treated with a single daily dose of 400 mg gatifloxacin for 10 days. Middle nasal meatus secretion was collected and sent for culture before and after treatment. Patients were all reevaluated at days 3 to 5; days + 1 to + 5 and 18 to 25 days + 7 to + 14 . Ninety three percent of the patients were considered clinically cured at the end of the treatment. The most frequent bacteria isolated were Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, and at the end of the treatment, presumed bacteriological eradication was observed in almost all patients. Adverse effects were observed in 19 of the cases, mostly mild and self limiting, including diarrhea, abdominal pain, nausea and vomiting. Treatment had to be interrupted in two cases. Gatifloxacin was found to be efficacious and safe for the treatment of acute rhinosinusitis in adults.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Anti-Bacterial Agents/therapeutic use , Fluoroquinolones/therapeutic use , Rhinitis/drug therapy , Sinusitis/drug therapy , Acute Disease , Fluoroquinolones/adverse effects , Treatment OutcomeABSTRACT
Foram estudados aspectos da infeccao e da imunidade experimentais em um roedor - o Mastomys natalensis - inoculado com a cepa LE (Belo Horizonte) do Schistosoma mansoni comparando os resultados com os do camundongo albino, animal tido como melhor modelo experimental. Os parametros estudados ofereceram resultados em tudo semelhantes aos encontrados em camundongos, com o M.natalensis se mostrando bastante sensivel a infeccao pelo S. mansoni, sendo de grande utilidade para os estudos da biologia do parasito e/ou observacoes da imunologia advinda da infeccao. Somando-se a tal fato a grande reprodutividade do animal em cativeiro, a criacao facil, o manejo e a manutencao simples em laboratorio, sugere-se que seja o M. natalensis usando como modelo experimental alternativo nos diversos estudos da esquitossomose mansoni
Subject(s)
Male , Female , Animals , Rats , Schistosoma mansoni , SchistosomiasisABSTRACT
Foi feita a comparacao de dois metodos de diagnostico usados para a identificacao do Trichomonas vaginalis. A comparacao estatistica das duas tecnicas que o metodo de cultura e superior ao exame a fresco
Subject(s)
Humans , Female , Cytodiagnosis , Trichomonas vaginalis , Vaginal SmearsABSTRACT
Foi desenvolvido um pino intramedular para fraturas diafisarias baixas do femur e e descrito o teste de arrancamento do mesmo de um especime humano