ABSTRACT
Assessment of Homocysteine levels in preeclampsia. A cross-sectional analytical study. Department of Physiology, BMSI, JPMC, Karachi in collaboration with Department of Gynecology and Obstetrics, JPMC, Karachi from March 2005 to November 2005. Study included 90 subjects distributed into three groups of 30 subjects each. 30 were apparently health subjects. 30 mild pre-eclamptic and 30 severely prerec lamptic. Clinical details were collected. Fasting blood samples were drawn by adopting aseptic methods and serum was analyzed for Homocysteine levels by !Mx Analyzer method. Among 90 screened subjects Homocysteine in 30 normal subjects was 6.61 mmol/L. 30 mild preeclamptic subjects showing 12.65 mmol/L was highly significant as compared to normal. However; 30 severe preeclamptic subjects shows mean Homocysteine level 14.44 mmol/L as compared to normal. The difference in both groups weir statistically highly significant as compared to normal subjects. Concluded that serum homocysteine levels were strongly associated with preeclampsia, which suggests that elevated circulating homocysteine may be involved in pathogenesis of uteroplacental vascular disease associated with preeclampsia, which may he a risk marker in pregnant women