Leptin, insulin, IGF-1 and bone mass in a group of sedentary adolescent girls

To investigate the relationships between serum leptin, IGF-1, insulin and bone mineral content and density in a group of Lebanese sedentary adolescent girls. Twenty Lebanese sedentary adolescent girls participated in our study. Total body bone mineral content and density were measured by dual-energy X-ray absorptiometry [DEXA]. In parallel, fasting leptin, IGF-1 and insulin concentrations were also measured. Serum leptin, IGF-1 and insulin concentrations were not associated with total body bone mineral content [BMC], total body bone mineral density [BMD] or pelvis BMD. Serum leptin, IGF-1 and insulin concentrations are not positive predictors of total body bone mineral content or density in this study group