ABSTRACT
Abstract Emerging evidence has revealed a cross-talk in the etiopathogenesis of burning mouth syndrome (BMS) related to peripheral nerve fibers (NF) and neuropeptides secreted by mast cells. Here, we investigated the S-100+ density and PGP 9.5+ integrity of peripheral NF and the tryptase+ mast cell density in the oral mucosa of BMS patients and healthy individuals. A total of 23 oral mucosa specimens (12 BMS and 11 controls) were evaluated. The clinical diagnosis of BMS was based on a careful examination, excluding other local and systemic causes. Samples were taken from an incisional biopsy of the tongue mucosa of individuals with symptomatic BMS, while the margins of the non-neoplastic tongue biopsy served as controls of healthy individuals. Immunohistochemistry was performed to determine the density/mm2 of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells. Similar densities of S-100+, PGP 9.5+ peripheral NF, and tryptase+ mast cells were found in cases of BMS, with a median value of 3.70, 0.70, and 29.24/mm2, respectively, and in the control group, with a median value of 2.60, 0.80, and 26.01/mm2, respectively (p > 0.05). Moreover, the relationship between S100+ and PGP 9.5+ peripheral NF was the same in both groups (p = 0.70). This study demonstrated that there were no alterations in the density and integrity of peripheral NF in the tongue of symptomatic BMS patients. However, the sensitization of peripheral NF in this disease may not depend on mast cell density.
ABSTRACT
la ferulización es uno de los procedimientos más antiguos de la odontología, sin embargo, aun en la actualidad, la ferulización periodontal continúa siendo una valiosa herramienta para el control de la hipermovilidad dentaria. Hoy en día, la utilización de las técnicas de ferulización debe estar fundamentada en sólidos conocimientos sobre la etiopatogenia de la enfermedad periodontal y trauma oclusal. Este artículo presenta una situación bastante común en la clínica odontológica que es la enfermedad periodontal avanzada en los dientes anteriores-inferiores, causando al paciente gran incomodidad masticatoria y hasta inseguridad para actividades funcionales básicas como la propia habla. Para la resolución de este cuadro clínico, se propone una ferulización definitiva por medio de una técnica alternativa, simplificada y funcional apuntando la manutención de los dientes periodontalmente debilitados. Este recurso es especialmente valioso para pacientes que no tienen condiciones financieras de recibir prótesis convencionales o soportadas por implantes.