ABSTRACT
Estudios recientes han demostrado una implicación de los receptores metabotrópicos mGlu1 y mGlu5 en la regulación de la conducta agresiva. Este trabajo examina el efecto de la administración de LY354740 (4-16 mg/kg ip), un agonista selectivo de los receptores metabotrópicos del grupo II (mGlu2/3), en encuentros agonísticos entre ratones macho, utilizando un modelo de agresión inducida por aislamiento. Treinta minutos tras la administración del fármaco, se llevaron a cabo interacciones agonísticas de 10 min de duración entre un animal aislado y un oponente anósmico en un área neutral. Dichos encuentros fueron grabados, para su posterior análisis etológico, estimándose el tiempo pasado por los ratones en cada una de diez categorías conductuales. LY354740 (12 y 16 mg/kg) redujo significativamente las conductas ofensivas, sin afectar la motilidad, en comparación con el grupo control. Estos resultados sugieren una implicación de los receptores mGlu del grupo II, en la modulación de la agresión.
Recent studies have demonstrated that glutamate metabotropic receptors mGlu1 and mGlu5 are involved in the regulation of aggressive behaviour. This study examines the effect of the administration of LY354740 (4-16 mg/kg i.p.), a selective group II metabotropic receptors agonist (mGlu2/3), using an isolation-induced aggression model. Individually housed mice were exposed to anosmic opponents 30 min after drug administration. Ten min of diadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to ten broad behavioural categories was estimated using an ethologically based analysis. LY354740 (12 and 16 mg/kg) significantly reduced offensive behaviours, without affecting immobility, as compared with the control group. These results suggest an implication of mGlu group II receptors in the modulation of aggression.
Subject(s)
Animals , Receptors, Metabotropic Glutamate , Rats/psychologyABSTRACT
O experimento foi conduzido com 210 leitões desmamados, afim de avaliar os efeitos da adição de frutooligosacarídeos (FOS) ou olaquindox nas rações sobre o desempenho dos 21 aos 63 dias de idade. Utilizou-se programa de alimentação por fases (pré-inicial, inicial-I e inicial-II, de zero aos 16, 17 aos 30 e dos 31 aos 42 dias, respectivamente). O delineamento foi de blocos ao acaso, seis tratamentos e sete repetições de cinco leitões cada: T1 - sem adição de FOS; T2 - com 0,1 por cento de FOS; T3 - com 0,2 por cento de FOS; T4 - com 0,3 por cento de FOS; T5 - com 0,5 por cento de FOS e T6 - sem FOS e 25ppm de olaquindox. A adição de FOS não afetou o consumo e o ganho diário de peso nas diferentes fases estudadas. Contudo, verificou-se melhor desempenho dos leitões que receberam olaquindox comparado à média dos demais tratamentos. Ao contrário do olaquindox, a adição de FOS foi ineficiente em promover melhora no desempenho.
The experiment was performed with 210 weaned pigs to evaluate the effects of fructooligosacharides (FOS) and olaquindox supplementation to the diet on their performance from 21 to 63 days of age. Feed program was pre-starter, starter I and starter II diets, 0 to16, 17 to 30 and 31 to 42 days, respectively. The experimental design was a randomized blocks with six treatments and seven repetitions of five each: T1 - without FOS; T2 - with 0.1 percent FOS; T3 - with 0.2 percent FOS; T4 - with 0.3 percent FOS; T5 - with 0.5 percent FOS and T6 - without FOS and 25 ppm olaquindox. Fructooligosacarides supplementation to the diet did not affect the daily consumption and daily weight gain in any of the different periods tested. However, improved performance was observed in pigs treated with olaquindox in comparison to FOS treated pigs. In conclusion, FOS supplementation was inefficient in improving pigs performance, contrasting with results for aloquindox supplementation.