Tumores que producen metástasis óseas / Tumors that cause bone metastases

Resumen: Introducción: Una metástasis es la capacidad celular tumoral para migrar del tumor primario e implantarse en tejidos de un órgano a distancia por vía hematógena, linfática o contigüidad. Las principales causas de metástasis óseas son: cáncer de mama, próstata y pulmón. Habitualmente se da en pacientes mayores de 50 años. Existe predilección por metastatizar al esqueleto axial. Objetivo: Determinar la frecuencia de los tumores que producen metástasis óseas en nuestra institución. Material y métodos: Estudio observacional, transversal, descriptivo, para análisis retrospectivo de los casos con diagnóstico de metástasis ósea. Resultados: Ciento noventa y tres casos; 121 mujeres y 72 hombres con rango de edad de 42 a 84 años. Los cánceres asociados a metástasis ósea fueron cáncer de mama, pulmón, próstata, cervicouterino y renal; en menor proporción otros como colon, tiroides, hígado y piel. Los huesos más afectados fueron esqueleto axial: columna lumbar y dorsal; en esqueleto apendicular el fémur en la región diafisaria y en el húmero el tercio proximal. En la actualidad, no se ha logrado mejorar la efectividad de estrategias de detección oportuna, por lo que los cuadros de dolor óseo deben iniciar con un protocolo de sospecha tumoral. Conclusiones: Más de 80% de los pacientes acudieron por fractura. Todos tenían historial de dolor mayor a 12 meses sin protocolo de estudio previo.

Abstract: Introduction: A metastasis is the tumor cell capacity to migrate from the primary tumor and implant itself in tissues of an organ at a distance by hematogenous, lymphatic or contiguity. The main causes of bone metastases are: breast, prostate and lung cancer. It usually occurs in patients over 50 years of age. There is a predilection for metastasizing to the axial skeleton. Objective: To determine the frequency of tumors that produce bone metastases in our institution. Material and methods: Observational, cross-sectional, descriptive study, for retrospective analysis of the cases of patients diagnosed with bone metastases. Results: 193 cases; 121 women and 72 men with an age range of 42 to 84 years. Cancers associated with bone metastases were breast, lung, prostate, cervical and renal cancers; to a lesser extent other such as colon, thyroid, liver and skin. The most affected bones were axial skeleton: lumbar and dorsal spine, and in appendicular skeleton the femur in the diaphysiary region and in the humerus the proximal third. At present it has not been possible to improve the effectiveness of timely detection strategies, so bone pain should begin with a protocol of tumor suspicion. Conclusions: More than 80% of the patients came for fracture. All patients had a history of pain greater than 12 months with no prior study protocol.

Tumores benignos que producen fracturas en niños / Benign tumors that cause fractures in children

Resumen: Introducción: Se define fractura patológica a la que se produce a través de un hueso anormal. Cada año se diagnostican aproximadamente 20,000 neoplasias benignas del sistema musculoesquelético. A menudo, el dolor de la fractura es el primer síntoma de un proceso patológico en el hueso. El sitio, la edad y la apariencia radiográfica crean un diagnóstico diferencial para las fracturas patológicas que sigue siendo amplio. El examen clínico evalúa la condición de la piel, palpar cualquier masa de tejido y determinar si hay signos inflamatorios locales como eritema, calor o edema. La toma de biopsia es muy recomendable para confirmar el diagnóstico de una fractura patológica. Objetivo: Determinar qué tumores óseos benignos y qué lesiones seudotumorales producen fracturas en huesos de niños con mayor frecuencia en nuestro hospital. Material y métodos: Estudio retrospectivo transversal, se revisaron expedientes de pacientes con diagnóstico de fractura en terreno patológico, atendidos en el período de Marzo de 2013 a Marzo de 2017. Resultados: Los tumores benignos que ocasionaron fracturas en terreno previamente dañado fueron: quiste óseo aneurismático 13, encondroma cinco, osteoma osteoide tres, tumor de células gigantes dos. Conclusión: En nuestra institución, los quistes óseos aneurismáticos fueron los tumores benignos que con mayor frecuencia producen fracturas patológicas en niños, con predominio en el sexo masculino.

Abstract: Introduction: A pathological fracture is defined as that which occurs through an abnormal bone. Approximately 20,000 benign neoplasms of the musculoskeletal system are diagnosed each year. Often the pain of the fracture is the first symptom of a pathological process in the bone. The site, age and radiographic appearance create a differential diagnosis for pathological fractures that remains broad. The clinical examination evaluates the condition of the skin, palpating any tissue mass and determining if there are local inflammatory signs such as erythema, heat or edema. The biopsy is highly recommended to confirm the diagnosis of a pathological fracture. Objective: To determine which benign bone tumors and pseudotumoral lesions produce fractures in children's bones more frequently in our institution. Material and methods: Cross-sectional retrospective study, review of records of patients with diagnosis of pathological fracture, attended in the period from March 2013 to March 2017, were reviewed. Results: The benign tumors that caused fractures in previously damaged areas were: aneurysmal bone cyst 13, enchondroma 5, osteoid osteoma 3, giant cell tumor 2. Conclusion: At our institution, aneurysmal bone cysts were the benign tumors that most frequently produce pathological fractures in children, with predominance in males.

Efectividad de una intervención en educación alimentaria y actividad física para prevenir obesidad en escolares de la ciudad de Casablanca, Chile (2003-2004) / Effectiveness of a dietary and physical activity intervention to prevent obesity in school age children

Background: With the aim of contributing to he Healthy Goal 2010 of reducing significantly the prevalence of childhood obestiy we developed and implemented during 2003 and 2004, a school-based obesity prevention intervention which included nutrition education and the promotion of physical activity. Aim To report the results of the intervention. Material and methods: The sample included 1760 children (1st to 7th grade) from 3 elementary public schools in Casablanca (experimental group) and 671 from a similar school located in Quillota, a neighboring city (control). Primary outcomes were body mass index (BMI) Zscore, the mile and shuttle-run tests and obesity prevalence. We also compared changes in waist circumference and triceps skinfold between both groups. Effectiveness of the intervention was assessed by analyzing separately the group *age* time interaction for the first 3 outcomes (follow-up-baseline), using a mixed model of covariance and by comparing variations in obesity prevalence between both groups. Results: There was a significant decline in BMI Z scores in experimental schools for both genders, but greater in boys (p <0.001 versus p =0.0034 in girls), while in controls, BMI Z scores increased. Obesity prevalence declined significantly in experimental schools; from 17 to 12.3 percent and from 14.1 to 10.3 percent in boys and girls respectively, while in the control group, it remained unchanged. Also, triceps skinfold in girls from Casablanca increased significantly ¡ess than that of control girls. Conclusion: This intervention proved that it is possible to reduce significantly the prevalence of obesity in Chilean schoolchildren attending public elementary schools.

Estrategia de promoción de la salud en escolares de educación básica municipalizada de la comuna de Casablanca, Chile / School-based health promotion intervention for primary school children from Casablanca, Chile

Se diseñó, implementó durante tres años (de 2002 a 2004) y evaluó una intervención en alimentación/nutrición y actividad física en escolares de educación básica de Casablanca. El objetivo general fue determinar la evolución en la prevalencia de obesidad en los mismos niños durante los tres años del estudio. La muestra incluyó 1103 escolares que en el 2002 estaban entre 1º a 6º básico en las tres escuelas municipales de la ciudad y que contaban con mediciones durante el período completo. Los componentes más importantes de la intervención incluyeron la aplicación de programa educativo FAO/INTA, charlas a los padres, aumento de las clases de educación física y un programa motivacional de actividad física. Los resultados muestran que la prevalencia de obesidad fue muy alta al inicio y que disminuyó de 21,6 por ciento a 12,2 por ciento en hombres y de 19,4 por ciento a 8,7 por ciento en mujeres. Este mismo análisis según categoría de edad al inicio y sexo, mostró una disminución a un tercio de la prevalencia original en mujeres que tuvieron entre 8 y 10 años y hombres entre 10 y 12 años al comienzo del estudio. Esta intervención fue exitosa en reducir significativamente la obesidad en escolares.

We designed, implemented during three years (from 2002 to 2004) and evaluated a school-based food/nutrition and physical activity intervention for primary school children from Casablanca, Chile. The general objective was to determine the trend in obesity prevalence during the three years of study of children followed longitudinally. The sample included 1103 children that attended 1st to 6th grade in 2002 in the three existing public primary schools of the city. The most important components of the intervention included the application of a educational program for primary school children developed by FAO/INTA, educational sessions for parents, increase in the number of physical (PE) education classes and a motivational PE program. Results showed that the baseline obesity prevalence was very high and decreased from 21.6 percent to 12.2 percent in boys and from 19.4 percent to 8.7 percent in girls. This same analysis done by age category at baseline and sex, showed that the prevalence was one third of the initial one in girls aged 8 to 10 years and boys aged 10 to 12 years at baseline. This intervention proved to decrease significantly the obesity prevalence among school children.

Estado nutricional y resistencia aeróbica en escolares de educación básica: línea base de un Proyecto de Promoción de la Salud / Nutritional status and aerobic capacity among children attending public elementary schools in Chile

Background: The Chilean Ministry of Health has developed a health promotion program called «Vida Chile¼, whose aim is to target risk factors for chronic diseases. To achieve this, school-based initiatives in nutrition and physical activity have been implemented. The evaluation of these initiatives includes a baseline assessment of these two variables. Aim: Baseline assessment of the nutritional status and aerobic capacity of elementary school children (1st to 8th grade). Material and methods: Children from seven public schools were studied. Weight, height, triceps skinfold thickness and waist circumference were measured. To test the aerobic capacity, the 20-m Shuttle Run Test (Navette) was utilized. Results: The assessment included 4,271 children, mean age was 10.2 years. The percentile of body mass index, as compared to the CDC 2000 Reference was 67.8±26.7 and 68±26.7 for boys and girls, respectively. The prevalence of obesity among children from 6 to 8 years, was 20.3 and 17.7% for boys and girls, respectively. Approximately 30% of males and 15% of females with normal weight had a good aerobic resistance, compared to 15 and 4% of their overweight counterparts. Aerobic capacity decreased with increasing age. Conclusions: There is a high prevalence of obesity and a deficient level of aerobic capacity among children attending public schools in Chile.