Celiac disease prevalence is not increased in patients with functional dyspepsia / A prevalência de doença celíaca não é aumentada em pacientes com dispepsia funcional

ABSTRACT BACKGROUND Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. OBJECTIVE To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. METHODS Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies. On the other hand, asymptomatic adult volunteers who performed a preventive visit to their primary care physician were invited to participate and agreed to undertake an upper gastrointestinal endoscopy with duodenal biopsies as well. Those patients with histologic signs of villous atrophy were furtherly evaluated and serological tests were performed in order to determine celiac disease diagnosis. Celiac disease prevalence was compared between groups. RESULTS Overall, 320 patients with dyspepsia and 320 healthy controls were recruited. There were no significant differences in terms of gender or age between groups. Celiac disease diagnosis was made in 1.25% (4/320) of patients in the dyspepsia group versus 0.62% (2/320) in the control group. CONCLUSION Patients with dyspepsia who underwent routine duodenal biopsies did not show an increased risk for celiac disease when compared to healthy individuals.

RESUMO CONTEXTO As evidências ao avaliar o risco da doença celíaca entre pacientes dispéptico têm sido inconclusivas, mostrando discrepâncias notórias em alguns casos. OBJETIVO Determinar a prevalência da doença celíaca em pacientes com dispepsia em comparação com controles saudáveis sem dispepsia. MÉTODOS Pacientes adultos sob avaliação para dispepsia foram convidados a participar. A estes pacientes foi oferecida uma endoscopia digestiva com biópsias duodenais. Por outro lado, voluntários adultos assintomáticos, que realizaram uma visita preventiva ao seu médico de atenção primária foram convidados a participar e concordaram em realizar endoscopia digestiva com biópsias duodenais também. Naqueles pacientes com sinais histológicos de atrofia das vilosidades foram melhor avaliados e foram realizados testes sorológicos para determinar o diagnóstico de doença celíaca. A prevalência de doença celíaca foi comparada entre os grupos. RESULTADOS No total, 320 pacientes com dispepsia e 320 controles saudáveis foram recrutados. Não houve nenhuma diferença significativa entre os grupos em termos de sexo ou idade. O diagnóstico de doença celíaca foi feito em 1,25% (4/320) dos pacientes no grupo de dispepsia, contra 0,62% (2/320) no grupo controle. CONCLUSÃO Pacientes com dispepsia submetidos a biópsias duodenais de rotina não têm risco aumentado para a doença celíaca quando comparados com indivíduos saudáveis.

Experiencia inicial en estudios videocolonoscópicos en un Servicio de Cirugía General y médicos en formación / Initial experience in videocolonoscopic studies in a general surgery service and doctors in training

Introducción: la Videocolonoscopía (VCC) es cada vez más utilizada en los servicios de cirugía. Objetivo: estimar el rédito diagnóstico y terapéutico de todas las videocolonoscopías, y la efectividad de los médicos en formación. Material y Métodos: se revisaron los estudios videocolonoscópicos realizados en el servicio de cirugía, entre julio de 2009 y julio de 2011. Resultados: se efectuaron 221 VCC con sedación. El género de los pacientes fue: masculino 117 (53%) y femenino 104 (47%). El motivo del estudio fue: hematoquecia 54 pacientes (24%), sospecha de cáncer colorrectal 20 (9%), reconstrucción del tránsito intestinal 19 (9%), dolor abdominal 13 (6%), cambio del ritmo evacuatorio 9 (4%), anemia 8 (4%), screening 9 (4%), tumor anexial 8 (4%), SOMF positiva 4 (2%), diarrea crónica 6 (3%) y Colitis ulcerosa 1 (0,50%). Se realizaron 179 (81%) VCC completas y 42 (19%) VCC incompletas. Los diagnósticos fueron: examen normal 53 (24%), lesiones polipóideas sésiles 43 (20%), lesiones polipóideas pediculadas 17 (8%), más de 2 a 3 lesiones polipóides 10 (5%), patología hemorroidaria 44 (20%), diverticulosis 37 (17%), rectosigmoiditis ulcerosa idiopática 2 (1%), tumor del canal anal 2 (1%), lipoma 1 (0.50%). Con relación al hallazgo de lesiones neoplásicas, hubo 3 lesiones neoplásicas tempranas tipo IIa de la Clasificación de Paris (1%), y 23 lesiones avanzadas (10%). De éstas 18 (8%) eran lesiones infranqueables, lo que impidió que el estudio fuera completo. Además de estos casos hubo otras 24 VCC incompletas (11%). El 100% de las lesiones polipóideas fueron extirpadas durante la VCC. Conclusiones: el 90% de los estudios fueron VCC completas, con lesiones tumorales infranqueables en el 8%. En las lesiones polipoideas se realizó terapéutica endoscópica en el 100% de los casos. Los médicos en formación cumplieron adecuadamente con los objetivos.

Background: the use of Videocolonoscopy is increasingly growing in surgical units. Objective: To estimate the diagnostic and therapeutic yield of colonoscopy and the effectiveness of training operators. Material and Methods: we reviewed all the colonoscopic exams from July 2009 to July 2011. Results: we performed 221 colonoscopies: 117 males (53%) and 104 females (47%). The indication was: hematochezia 54 (24%), suspected colorectal cancer 20 (9%), reconstruction of bowel transit: 19 (9%), abdominal pain: 13 (6%), change of bowel movement habits 9 (4%), anemia 8 (4%), screening 9 (4%), ovarian tumor 8 (4%), positive FOBT 4 (2%), chronic diarrhea 6 (3%) and ulcerative colitis 1 (0.50%). There were 179 (81%) complete exams and 42 (19%) incomplete. The diagnosis were: abscence of pathology 53 (24%), sessile polypoid lesions 43 (20%), pedunculated polypoid lesions 17 (8%), more than 2-3 sessile polypoid lesions 10 (5%), pathologic hemorrhoids 44 (20%), diverticulosis 37 (17%), idiopathic ulcerative rectosigmoiditis 2 (1%), anal canal tumor 2 (1%) and lipoma 1 (0.50%). Regarding neoplasic lesions there were 3 Paris type IIa (1%), and 23 advanced tumors (10%). Of them, 18 (8%) impaired a complete examination. There were other incomplete colonoscopies 24 (11%), mainly due to a bad preparation. Conclusions: complete colonoscopy was achieved in 90% of the studies, with obstructive tumors in 8% which did not allow a complete exam. Regarding polypoid lesions endoscopic therapy was performed in 100% of cases. Training operators adequately met the objectives.