ABSTRACT
Splenic metastasis is a rare clinical entity--incidence being 0.6% at autopsy and 1.1% at splenectomy. We report the case of a 30 year old female who presented with purpura and melena and who was later diagnosed to have a mucinous adenocarcinoma of stomach with disseminated intravascular coagulation and splenic metastasis.
Subject(s)
Adenocarcinoma, Mucinous/pathology , Adult , Disseminated Intravascular Coagulation/etiology , Female , Humans , Splenic Neoplasms/secondary , Stomach Neoplasms/pathologySubject(s)
Adolescent , Carcinoma/diagnosis , Female , Humans , Nasopharyngeal Neoplasms/diagnosis , Parotid Neoplasms/diagnosisABSTRACT
The study highlights the presence of chloroquine resistant Plasmodium falciparum strains in Kerala state, India for the first time. The emergence of chloroquine resistant P. falciparum in a low transmission area is dependent on the imported cases while build up of resistance is mainly due to persistence of resistant parasites which have more opportunities for transmission.
Subject(s)
Animals , Chloroquine/therapeutic use , Commerce , Drug Resistance , Humans , India/epidemiology , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effectsABSTRACT
In view of the emergence of chloroquine resistant Plasmodium falciparum from more and more geographical areas profiling of the responses to other available antimalarials by in vitro methods have become essential. A preliminary study undertaken in two Primary Health Centres of Karnataka State, India show the presence of strains of P. falciparum resistant to chloroquine and amodiaquine. The response for amodiaquine was poor as compared to chloroquine. The isolates were, however, sensitive to mefloquine and quinine.
Subject(s)
Amodiaquine/administration & dosage , Animals , Chloroquine/administration & dosage , Drug Resistance, Microbial , Malaria/blood , Mefloquine/administration & dosage , Microbial Sensitivity Tests , Plasmodium falciparum , Quinine/administration & dosageABSTRACT
An attempt has been made to identify the focus of origin of Plasmodium falciparum resistance. Several factors have been analysed and the importance of mean parasite recrudescence time (M.P.R.T.) in the identification of focus of origin of resistance is highlighted.