ABSTRACT
OBJECTIVE: The study aims to detect the resistance pattern of fluoroquinolones (ciprofloxacin & levofloxacin) in Urinary Tract Infection (UTI) caused by Enterococcus species. MATERIALS AND METHOD: 77 isolates of Enterococcus species from the urine samples of clinically suspected cases of UTI were studied. Identification and antimicrobial susceptibility testing was performed by conventional as well as automated methods. RESULT: Enterococcus faecalis (53.25%) was the commonest. Most of the isolates were resistant to both levofloxacin (83.12%) and ciprofloxacin (85.71%). • CONCLUSION: Resistance to fluoroquinolones is of concern as it serves as an excellent oral choice of drug. So, the inclusion of this group of drug in the treatment regime should be reconsidered and effective strategies developed to contain the same.
ABSTRACT
Context: Acinetobacter baumannii, a non-fermenter, is fast coming up the list of pathogens causing nosocomial infections. Earlier considered to be a harmless colonizer, or at the most, a pathogen causing mostly respiratory tract infections, it has slowly but successfully emerged as a ubiquitous pathogen causing both community as well as health care associated infections. It has acquired multidrug resistance, and seems to be no more selective in mainly attacking any one or two body systems. According to recent reports, a shy selective bacterium has turned into a dangerous pathogen, capable of causing infections anywhere in the body, thereby adding extra furrows on the forehead of medical community worldwide. AIMS: To determine the range of infections caused by A. baumannii, and the frequencies thereof, in our tertiary care hospital; and to study their resistance patterns. Materials and Methods: A total of 88 isolates of A. baumannii were found from a variety of clinical samples, from hospitalized patients as well as patients attending the outpatient departments. The isolates were subjected to disc-diffusion method for antibiotic sensitivity testing. Results: Acinetobacter was mostly recovered from samples of pus, followed by endotracheal tube, urine, sputum samples, etc., Imipenem showed highest sensitivity, while other drugs with good sensitivity patterns were aminoglycosides and piperacillin-tazobactum. Conclusions: In this tertiary care institution of ours, A. baumannii isolates have shown a high frequency of drug resistance, with imipenem being the best sensitive drug. This non-fermenter is the cause of a variety of infections, irrespective of whether the individuals are hospitalized or are outdoor patients.