ABSTRACT
Parkinson′s disease (PD) is a common aging-related neurodegenerative disease of the central nervous system. Its pathogenesis is a series of pathophysiological changes under the interaction of genetic factors and environmental risk factors. Recent studies have shown that the pathophysiologic mechanisms outside the central nervous system, especially inflammation and immune response, may play an important role in the pathogenesis of Parkinson′s disease. This article aims to review the up-to-date research results of the peripheral origin of PD, and to discuss the interplay and activation of the peripheral inflammatory immune system in PD.
ABSTRACT
Parkinson′s disease (PD) is the second most common neurodegenerative disease following Alzheimer′s disease. The non-motor symptoms of PD have attracted increasing attention. The occurrence of abnormal blood pressure is related to many factors, including aging, PD related autonomic nerve dysfunction, and drugs for PD treatment,including levodopa, dopamine receptor agonists. Abnormal blood pressure severely limits the clinical use of anti-PD drugs. In order to better understand the relationship between anti-PD drugs and blood pressure in patients with PD. This article summarizes the manifestations of abnormal blood pressure, and analyzes the correlation between anti-PD drugs and blood pressure, summarizes the possible mechanisms of how anti-PD drugs affects the blood pressure in PD.