Adequate Dose Reqirements of Propofol by Injection during Anesthesia Induction / 대한마취과학회지

BACKGROUND: Propofol is a short-acting intravenous sedative-hynotic agent that can be used for induction and maintenance of general anesthesia. This study was perfomed to evaluate adequate dose requirements of propofol by injection during anesthesia induction, and to evaluate the induction technique by assessing induction dose, induction time, success rate of induction and hemodynamic effects. METHODS: Ninety healthy adult patients(ASA class I or II), scheduled for elective surgery under general anesthesia, were randomly assigned to receive propofol 1 mg/kg(group I), 2 mg/kg(group II), and 3 mg/kg(group III) respectively as an induction agent. Mean arterial pressure(MAP) and heart rate(HR) were measured before the administration of propofol and just after successful induction. We determined the speed of injection as lasting 40 seconds. RESULTS: Success rate of induction in group I(30%) was lower than group II(100%) and III(100%). The induction time in group I(81s) was longer than group II(51s) and III(47s). The MAP were statistically significant difference among three groups(p<0.05 compared with before induction). In group III, the MAP was more decreased than group I and II and HR was more increased than group I and II. CONCLUSIONS: We concluded that propofol in group II(2 mg/kg) is more desireable dose than group I(1 mg/kg) and group III(3 mg/kg) for induction of general anesthesia.

A Comparative Study of the Epidural Buprenorphine and Morphine for Post-Cesarean Section Pain Relief / 대한마취과학회지

Buprenorphine is a semisynthetic, highly lipophilic opioid derived from thebaine and it is 30 to 40 times more potent than morphine. This study was performed to compare the clinical effects of epidural buprenorphine on postoperative pain control with those of epidural morphine in 150 cesarean deliveries. They were physical status 1 or 2 by ASA classification and randomly divided into three groups. They were administered morphine 3 mg in group I, buprenorphine 0.15 mg in group II and buprenorphine 0.3 mg in group III as first dose mixed with 0.25% bupivacaine 10 ml respectively through indwelling epidural catheter at the time of ligation of umbilical cord. Second and third doses were administered with 8 hours intervals, morphine 3 mg with N/S 10 ml was injected in group I and buprenorphine 0.15 mg with N/S 10 ml was injected in group II and III respectively. Their analgesic effects were evaluated by VAS and severity of side effects was also evaluated. The Results were as follows; 1) VAS was significantly increased in group II compared to group I and III(p<0.05). There was no significant difference between group I and III. 2) Pruritus was lesser in group II and III than group I(p<0.05). 3) There was no significant difference in nausea and vomiting. 4) None of patients had respiratory depression. The authors' findings indicate that epidural administration of buprenorphine of suitable dose may be useful in the treatment of postoperative pain.