Primary Trabeculectomy with Mitomycin C for Medically Uncontrolled Angle Closure Glaucoma

PURPOSE: To report the results of primary trabeculectomy with mitomycinmitomycin C (MMC) for medically uncontrolled, primary angle-closure glaucoma. METHODS: A retrospective study of 20 eyes from 18 consecutive patients with medically uncontrolled primary angle-closure glaucoma who underwent trabeculectomy with MMC, from 1997 to 2000. RESULTS: The mean follow up was 33.9 +/- 12.9 months (range 24~60). After trabeculectomy with MMC, IOP remained below 22 mmHg in 17 eyes (85%) with or without medication. Postoperative complications occurred in 5 eyes (25%). CONCLUSIONS: Trabeculectomy with MMC resulted in favorable long-term IOP control and relatively low complications in medically unresponsive acute angle-closure glaucoma.

Comparison of the Intraocular Pressure Reducing E ffect of Latanoprost with Timolol

We compared the intraocular pressure reducing effect and side effects of 0.005%Latanoprost administered once daily with 0.5%Timolol administered twice daily in patients with open-angle glaucoma or ocular hypertension. This was an open randomized study with two parallel groups and a treatment period of 12 weeks. A total of 76 patients were included:38 in the Latanoprost group and 38 in the Timolol group. Intraocular pressure was reduced from 25.92 mms of mercury to 17.12 mms of mercury[33.91%]with Latanoprost and from 22.53 mms of mercury to 18.38 mms of mercury[18.42%]with Timolol. The efficacy of Latanoprost was statistically superior to timolol[p<0.001]. Latanoprost induced a slight conjunctival hyperemia and ocular discomfort but both drugs were generally well tolerated. Iris hyperpigmentation reported as a significant side effect of Latanoprost was not observed during 12 weeks of follow-up. It is concluded that Latanoprost administered once daily in the evening reduced intraocular pressure as well as and probably more than Timolol administered twice daily.