ABSTRACT
The purpose of this study is to describe the common causes and clinical presentations of Disseminated Intravascular Coagulation at periphery of Karachi. It was a descriptive study conducted by the department of Medicine at Jinnah Medical and Dental College Hospital, Korangi, from January 08 to December 08. Jinnah Medical and Dental College Hospital, provides health care facilities to the rural areas of Karachi including Sharafi, Chashma, Rehri Goths etc. We studied mode of presentation, laboratory investigation, treatment options and mortality. All the findings were recorded on a pre-designed Proforma. Sixty patients with Disseminated Intravascular Coagulation [DIC] were studied as protocol. Out of sixty cases 36 [60%] were male and 24 [40%] were female. Patients were 13-65 years of age mean 37.33%. Out of sixty patients 50 [83.3%] presented with bleeding and hemorrhage from various sites and only 10 [16.6%] presented with signs of hypercoagubility. Bacterial infection was found to be most common underline illness. The mortality rate was 43.3% in this study the mortality rate was higher in patients in which underlying illness was not easily curable. Disseminated Intravascular Coagulation [DIC] has various modes of presentation with very high mortality all over the world. In our study the majority of patients presented with bleeding from various sites, and the main causative agent was infective illness, so it is advisable if patient presented with bleeding and has history of infective illness than Disseminated Intravascular Coagulation [DIC] should be included in differential diagnosis