Cutaneous Complications of Terlipressin.

Three cases of skin changes in cirrhotic patients treated with the vasoconstrictor agent terlipressin. We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so.Two patients developed extensive skin necrosis over the abdomen & chest wall and lower limbs. The third patient had developed extensive necrosis of both lower limbs and digital gangrene.With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome.