ABSTRACT
We report the findings on CT and MR imaging in a patient with rapidly progressive subacute sclerosing panencephalitis (SSPE), which correlated with the clinical progression of the disease. In view of the rapid neurological deterioration and CSF pleocytosis, a brain biopsy was done and this confirmed the diagnosis.
Subject(s)
Adolescent , Disease Progression , Humans , Magnetic Resonance Imaging , Male , Subacute Sclerosing Panencephalitis/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Mice are susceptible to natural infections with streptococci and therefore can serve as suitable animal models to study experimental streptococcal infections. In an earlier study, we had shown the development of pharyngeal colonization, antibody response and histopathological changes in the heart following intranasal (IN) challenge with a rheumatogenic serotype of group A beta haemolytic streptococcus, the M type 18. To determine if nonpharyngitis associated serotypes can also elicit similar responses, 30 Swiss albino mice were challenged intranasally with 2 x 10(7) colony forming units of a skin associated serotype of group A beta haemolytic streptococcus, the M type 49. Pharyngeal colonization varied from 64% (n = 30) in the first week to 69% (n = 16) during the fourth week after IN challenge. Eleven (36.7%) of the 30 animals studied showed antibody response to DNase B (ADNB) with peak titers varying from 150 to 1200 units. Wide variations were seen in ADNB titers in individual mice. Histopathological evidence for cardiac lesions were seen in three animals. The changes were mild and varied from mild to chronic endocardial inflammation to calcification. The study shows that Swiss albino mice are also susceptible to IN challenge with skin associated strains of GABHS and therefore can serve as useful models to study the effects of experimental infection with diverse serotypes of GABHS.
Subject(s)
Administration, Intranasal , Animals , Antibodies, Bacterial/blood , Deoxyribonucleases/immunology , Disease Models, Animal , Endocarditis, Bacterial/etiology , Mice , Serotyping , Streptococcal Infections/etiology , Streptococcus pyogenes/classificationABSTRACT
An unusual case of bilateral Krukenberg tumors having a predominant multicystic mucinous component which on gross and microscopic examination resembled a mucinous cystadenocarcinoma is presented. It is important to distinguish between these two tumors as Krukenberg tumours have a significantly worse prognosis.
Subject(s)
Cystadenocarcinoma, Mucinous/diagnosis , Diagnosis, Differential , Female , Humans , Krukenberg Tumor/diagnosis , Middle Aged , Ovarian Neoplasms/diagnosisABSTRACT
Medullomyoblastoma is a rare tumour seen in childhood. We report a medullomyoblastoma occurring in the cerebellar vermis of a 4 year old boy. The light microscopic features, immunohistochemistry and histogenesis are described.
Subject(s)
Cerebellar Neoplasms/pathology , Child, Preschool , Humans , Male , Medulloblastoma/pathology , Tomography, X-Ray ComputedABSTRACT
This case reports the first transplant associated Kaposis sarcoma reported from India.
Subject(s)
Adult , Humans , Immunosuppressive Agents/adverse effects , Kidney Transplantation/adverse effects , Male , Sarcoma, Kaposi/etiologyABSTRACT
Swiss albino mice from a randomly bred colony were inoculated intranasally with 1.6, 2 or 2.4 x 10(7) colony forming units of a mid-logarithmic phase culture of group A beta haemolytic streptococcus M type 18 for 3 days, 6 days or once a week respectively for three weeks. Pharyngeal colonisation could be observed in 67 (59.8%) of 112 mice on 4th day after inoculation and 14 (38%) of the 37 mice on 21st day. Out of 27 mice tested for determination of antibodies to deoxyribonuclease B at regular intervals for 98 days, 15 (55.5%) showed responses, with maximum titers varying from 50 units to 4800 units in individual mice. Histopathological evidence for cardiac lesions were seen in five (3.03%) of the 165 animals studied. These included one case of severe endocarditis, two cases of endocarditis with valvular lesions and one case with non-specific lymphocyte infiltration in the heart. One other animal showed subendocardial oval nodular aggregates. Although the cellular nature of these lesions were not determined, this study shows that Swiss albino mice can serve as suitable animal models to study experimental streptococcal infections. However these are preliminary observations and are to be confirmed and revalidated by further controlled experiments.
Subject(s)
Animals , Deoxyribonucleases/immunology , Heart/microbiology , Mice , Myocardium/pathology , Pharynx/microbiology , Streptococcus pyogenes/immunologyABSTRACT
Melanotic neuroectodermal tumors occur very rarely in the epididymis, only eleven cases having been reported to date in the world literature. An additional case is reported which we believe is the first from India.
Subject(s)
Epididymis , Humans , Infant , Male , Neuroectodermal Tumor, Melanotic/pathology , Testicular Neoplasms/pathologyABSTRACT
The pathological findings in a multinodular malignant oncocytoma of the parotid gland in a male 62 years of age, with tumour infiltration into the adjacent skin and skeletal muscle and with regional lymph node metastasis is presented.
Subject(s)
Adenoma/pathology , Humans , Male , Middle Aged , Parotid Neoplasms/pathologyABSTRACT
A case of polymyositis associated with Bancroftian filariasis in an adult male who presented with generalised painful swelling and weakness of muscles is presented. He had elevated muscle enzymes, a myopathic EMG pattern, focal vasculitis on gastrocnemius muscle biopsy and W. bancrofti in the peripheral blood. There was clinical, biochemical and histopathological evidence of resolution of the disorder and total clearance of microfilaremia with diethyl carbamazine (DEC) therapy.