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1.
Article in Chinese | WPRIM | ID: wpr-1022959

ABSTRACT

The disposable sterile urethral catheter was described in terms of the current status of the standards of foreign countries and China and its regulation and registration.The national supervision and sampling inspection and exploratory research of the disposable sterile urethral catheter in 2018,2019 and 2021 were introduced,and the problems found and the causes were analyzed and then the countermeasures were proposed accordingly.References were provided for guiding and standardizing the development of catheter products industry.[Chinese Medical Equipment Journal,2024,45(1):84-88]

2.
Yao Xue Xue Bao ; (12): 277-281, 2006.
Article in Chinese | WPRIM | ID: wpr-271460

ABSTRACT

<p><b>AIM</b>To prepare amylopectin anchored dipyridamole (DIP) liposome and to study its tissue distribution in mice.</p><p><b>METHODS</b>The regular DIP liposomes were prepared by film-scatter method. The amphiphilic O-palmitoyl amylopectin was synthesized and added to modify the surface of liposome. The entrapping efficiency, zeta potential, mean diameter, span of modified and regular liposomes were assayed. The RP-HPLC was used for the determination of DIP concentration in mice tissue.</p><p><b>RESULTS</b>After modification, the entrapping efficiency depressed, zeta potential was raised, mean diameter and span had no obvious change. The level of DIP in lung, liver and spleen for regular liposomes were higher than that of injections. Compared with regular liposomes, the modified liposomes increased the DIP level in lung, and decreased the DIP level in liver, spleen, moreover, lengthened the retention time of DIP in lung.</p><p><b>CONCLUSION</b>The distribution of modified liposome in mice was markedly changed as compared with regular liposomes and injections. The modified liposomes had obvious lung targeting property.</p>


Subject(s)
Animals , Male , Mice , Amylopectin , Chemistry , Area Under Curve , Dipyridamole , Chemistry , Pharmacokinetics , Drug Delivery Systems , Liposomes , Lung , Metabolism , Palmitates , Chemistry , Particle Size , Tissue Distribution
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