ABSTRACT
Rarely, two different histological types of lymphoma develop in the same person. Sequential lymphoma is defined as two different types of lymphoma occurring in the same person sequentially. A 47-year-old patient with human immunodeficiency virus (HIV) infection who had been diagnosed with mixed cellularity Hodgkin's lymphoma was treated with adriamycin, bleomycin, vinblastine, and dacarbazine combination chemotherapy. After six cycles of chemotherapy, abdominal computed tomography showed multiple liver masses. A percutaneous needle biopsy of the liver and polymerase chain reaction single-strand conformation polymorphism revealed hepatosplenic T-cell lymphoma. The patient died 3 months after the diagnosis of hepatosplenic T-cell lymphoma. To our knowledge, this is the first case of the sequential development of hepatosplenic T-cell lymphoma after Hodgkin's lymphoma in a Korean HIV-infected patient.
Subject(s)
Humans , Middle Aged , Biopsy, Needle , Bleomycin , Dacarbazine , Diagnosis , Doxorubicin , Drug Therapy , Drug Therapy, Combination , HIV , Hodgkin Disease , Liver , Lymphoma , Lymphoma, T-Cell , Polymerase Chain Reaction , VinblastineABSTRACT
Thrombocytopenia is a common event in the course of human immunodef-iciency virus (HIV) infection. The maior cause of HIV virus related thrombocytopenia is idiopathic thrombocytopenic purpura (ITP). Treatment options for HIV related ITP are steroids, immunoglobulin, other immunosuppressive agents, and splenectomy. In addition, Antiretroviral agents are reported as effective treatment options in the setting of HIV-associated ITP, by enhancing CD4+ T cell counts, and reducing HIV viral loads. We report a case of HIV related ITP treated with prednisone, immunoglobulin, and highly active antiretroviral therapy (HAART).
Subject(s)
Humans , Humans , Anti-Retroviral Agents , Antiretroviral Therapy, Highly Active , Cell Count , HIV , Immunoglobulins , Immunosuppressive Agents , Prednisone , Purpura, Thrombocytopenic, Idiopathic , Splenectomy , Steroids , Thrombocytopenia , Viral LoadABSTRACT
Thrombocytopenia is a common event in the course of human immunodef-iciency virus (HIV) infection. The maior cause of HIV virus related thrombocytopenia is idiopathic thrombocytopenic purpura (ITP). Treatment options for HIV related ITP are steroids, immunoglobulin, other immunosuppressive agents, and splenectomy. In addition, Antiretroviral agents are reported as effective treatment options in the setting of HIV-associated ITP, by enhancing CD4+ T cell counts, and reducing HIV viral loads. We report a case of HIV related ITP treated with prednisone, immunoglobulin, and highly active antiretroviral therapy (HAART).