The Influence of High- and Low-Dose Aprotinin on Thromboelastography in Coronary Artery Bypass Grafting Surgery / 대한마취과학회지

BACKGROUND: The protease inhibitor aprotinin reduces blood loss and homologous blood usage after a cardiac operation. The aim of the present study was to investigate the effect of low- and high-dose aprotinin on thromboelastography (TEG) variables and to examine the relationship between the clinical effect of aprotinin and the TEG variables in coronary artery bypass grafting surgery (CABG). METHODS: Twenty-three patients scheduled for an elective CABG were randomly assigned to receive either high does (group H, n = 12) or low does (group L, n = 11) aprotinin. TEG variables, and a coagulation profile test at baseline and arrival in ICU were performed. Amount of blood loss, homologous blood transfusion and heparin requirements were measured. RESULTS: In group L, there were significant increases in r time and k time and significant decreases in MA and alpha angle after aprotinin administration. In group H, just k time after aprotinin administration was significantly increased compared with baseline data. There were no significant differences in amount of blood loss and allogenic blood transfusions between the two groups. There was not a significant correlation between TEG variables and amount of blood loss in both groups. Interestingly a siginificant negative correlation between the length of cardiopulmonary bypass and MA was noted in group H (r = -0.63; P < 0.05). CONCLUSIONS: In CABG patients, aprotinin preserves platelet function more significantly in the high-dose aprotinin group. In addition, TEG variables indicated a later clot formation in the low dose aprotinin group.

Comparison on VO2max, Bone Density Between High and Low HDL-C Group in a Commercial Aircrew Member

INTRODUCTION: The number of passengers using aircraft is steadily increasing with the improvement in the air transport business. It requires the investment both in materials and human resources for commercial aircrew members to be able to accomplish their tasks of aircraft safety. Therefore, the aircrew members are required to maintain and improve their mental and physical states to an optimal condition. It is also very important to periodically evaluate a physical condition, which is essential to flight safety. METHODS: In this study, each of a total of 89 out of a population of 278 korea aircrew members over 50 were examined in three aspects: blood lipids, maximal oxygen consumption, and bone density. The examinee were divided into two groups (HDL-C high group and HDL-C low group) and three parameters described above were compared between two groups. RESULTS: The results were as follows: (1) TC and LDL-C were significantly higher(p<0.05), and HDL-C, TG and TC/HDL were significantly lower in HDL-C High group than HDL-C Low group (p<0.01). (2) The maximal oxygen consumption was significantly higher in HDL-C high group (p<0.05). (3) The bone density of lumbar spine was significantly higher in HDL-C high group (p<0.01). (4) VO2max were significant (P< .05) correlate to HDL-C. CONCLUSION: On the basis of the study, an aerobic exercise which helps in improving the maximal oxygen consumption and cardiopulmonary function is considered to be essential for aircrew members to maintain physical conditions for their tasks, and it is desirable to develop more effective aerobic exercise programs.