ABSTRACT
Invasion and metastasis are the main behavior of malignant tumors. Lymph node metastasis is an early metastasis mode of bladder cancer, which is an important risk factor for poor prognosis . It is also an important index to decide the treatment, especially to determine the operation mode and strategy. Therefore, searching for the evaluation index of lymph node metastasis of malignant tumor is the focus of tumor research. In recent years, the literature of molecular biology for predicting the staging of bladder cancer has been reviewed, but the literature on biological assessment of lymph node metastasis hasn′t. At present, many evaluation indexes related to lymph node metastasis of bladder cancer have been reported in addition to the new imaging Methods , from gene to protein, and then to cell and tissue. In this paper,we try to look into the biological research progress in the evaluation of lymph node metastasis of bladder cancer.
ABSTRACT
Objective To compare the clinical efficacy of orthotopic ileal neobladder versus ortho- topic sigmoid neobladder.Methods The data of 96 patients who had undergone orthotopic ileal neoblad- der and 68 patients who had undergone orthotopic sigmoid neobladder were retrospectively analyzed.The perioperative condition,urinary continence,urodynamics,and pouch-related complications were compared between the 2 groups.Results Of all the 164 patients,12(7.3%)were lost to follow-up.The mean fol- low-up was 46(2-86)months in orthotopic ileal neobladder group,and 42(4-78)months in orthotopic sigmoid neobladder group.There was no significant difference in intraoperative blood loss and postoperative urinary continence between the 2 approaches(P＞0.05).However,compared with sigmoid neobladder group,ileal neobladder group had longer operative time and postoperative recovery time,and got a bigger pouch(P＜0.05).The early and late pouch-related complication rates of ileal neohladder group were 16. 7% and 29.2%,which were higher than those of sigmoid neobladder group.During the follow-up,tumor recurred in 3 cases of ileal neobladder group,but none in sigmoid neobladder group.Conclusions Ortho- topic ileal neobladder and sigmoid neobladder are similar in operative difficulties,and both can achieve satis- factory clinical results.Compared with ileal neobladder,sigmoid neobladder has shorter operative time, quicker recovery and lower rate of pouch-related complications,thus is a preferred procedure.