ABSTRACT
Objective To compare the efficacy and safety of paroxetine alone and combined with folic acid in patients complaining of premature ejaculation ,and measured the 5-hydroxyptamine(5-HT ) concentration in two groups before and after treatment and compared the differences .Methods 126 cases of PE were included from department of Urology of 363 Hospital of Chengdu .Subjects were randomly divided into 2 groups ,group A were given paroxetine hydrochloride 20 mg/d ,group B were given paroxetine hydrochloride 20 mg/d and fo-lic acid 0 .4 mg/d ,study duration was 8 weeks .Blood sample got from the candidates both in screening period and after 8 weeks of treatment .The efficiency after treatment was measured by IELT and PEP ,the plasma 5-HT level was measured too .SPSS16 .0 statistical analysis was used .Results After treatment ,IELT of group A and group B was improved from 1 .21 ,1 .18 min to 8 .04 ,9 .42 min .The improvement of average IELT in group B was significantly higher than that in group A ,the difference was statistically significant (P＜0 .05) ;The PEP score and 5-HT level in group B were significantly higher than that in group A ,the difference was statistically significant (P＜0 .05) .Conclusion Paroxetine combined with folic acid in the treatment of primary premature ejaculation has a significant effect ,compared to paroxetine alone .The average plasma level of 5-HT increased significantly ,and folic acid could assist paroxetine in elevating plasma levels of 5-HT and improving primary premature ejaculation symptoms .
ABSTRACT
Objective To reveal the features of fund sponsored articles and the status of scientific research by analyzing fund sponsored articles in Hubei Region.Methods The papers published from the year of 2001-2010 by the authors of Hubei Region in 11 domestic ophthalmology periodicals were investigated.The amount of funds obtained,funded papers output,research content and direction,and the literature type were calculated by quantitative analysis methods.Results There were 142 of funded projects supported by the National Natural Science Fundation(NSFC),province/ministry and other sourses from the year of 2001 to 2010 in Hubei Region.The amount of projects funded by national was 2.55 times higher in the year between 2006-2010 compared with the year of 2001-2005,meanwhile,province/ministry projects were 1.97 times increased.Among 28698 articles published in 11 ophthalmologic journals(Chinese Journal of Ophthalmology,etc.) between 2001-2010,in which 134 funded articles were published by the authors of Hubei region,accounted for 4.67％ of total papers were supported by varous funds.The papers of applications and basic application were accounted for 43.28％,to explore the pathogenesis and mechanisms were accounted for 30.60％.The subjects of fund sponsored articles were mainly in the field of retine,cornea,glaucoma,lens or cataract.Conclusions Offer as a referance to the ophthalmologist and researchers choose the research direction.Clinical research,continuously research and multidisciplinary cross studies should be strengthed.