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Objective To investigate the influence of sulfated propylene glycol alginate(PSS) and its fractions on the immunoregulation.Methods The immunoregulation activity of PSS and its fractions were investigated by using immunocyte cultivation technique in vitro.The structure activity relationship was analysed on the basis of the structure studies of PSS' fractions.Results The experimental results showed that PSS could improve spleen cell proliferation,enhance macrophage phagocytic function and inhibit T-cell and B-cell proliferation.Conclusion PSS possessed significant immunoregulation effect,whilst the immunocompetence comparison of PSS' fractions proved that the different immunocytes had different requirements for saccharides length.
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OBJECTIVE： To evaluate the economic effectiveness of different pharmacotherapeutic schemes for the same disease.METHODS： Using pharmacoeconomical cost-effectiveness analysis， six schemes for upper urinary tract infections were compared.RESULTS： The total effective rate and cost were both the lowest in group B(70.00％ ).The cost-effectiveness ratios of A， B， C， D， E， F were 28.60、 19.13、 43.27、 29.99、 43.02、 29.14， respectively.They became 23.65、 18.01、 34.00、 24.87、 33.91、 24.20 by sensitivity.CONCLUSION： The A and F were both the most inexpensive and effective schemes.
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Objective: To observe the promoting blood circulation by removing blood stasis of Lubai Capsule(LBC)(Rhizoma Phragmitis, Radix Paeoniae Alba, Radix Saposhnikoviae, Flos Schizonepetae, etc.). Methods: Acute blood stasis rat models were established with swimming in iced water and sc adrenalin in order to observe the effect of LBC on blood rheology. Mesenteric microcirculatory disturbance rat models were also established with adrenalin in order to observe the effect of LBC. Clotting time was measured in vitro with prothrombin time(PT) and kaolin partial thromboplastin time(KPTT) kit in order to observe its effects. Results: LBC could decrease the whole blood and plasma viscosity, fibrinogen, erythrocyte sedimentation and aggregation ratio of blood platelets of rats, ease the sticky condition of blood stasis rat models and prevent from forming thrombus. It could also inhibit the constraction and slowing of blood flow of thin artery, the reducing of open capillaries and change of fluid condition caused by adrenalin and improve these phenomena. PT and KPTT could be increased obviously. Conclusion: LBC can significantly promote blood circulation by removing blood stasis, because of improving blood rheology and mesenteric microcirculatory disturbance and inhibit endogenous and exogenous coagulation system.
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AIM: To study the action of Pingkui Powder (Herba Gynostemmatis Pentaphylli, Fructus Hippophae, etc.) on the experimental acute gastric ulcer and its influence on gastric mucosa injury in rats. METHODS: The experimental models were established by means of histamine and indomethacin, area of ulcer was measured and quantity of gastric mucosa secretion of rats was analyzed. RESULTS: Pingkui Powder could reduce areas of ulcers, promote the gastric mucosa secretion. CONCLUSION: Pingkui Powder can improve the healing of acute ulcer and promote gastric mucosa secretion.