ABSTRACT
Objective To evaluate and compare the efficacy and safety of liposome doxorubicin and gemcitabine combined with oxaliplatin in the treatment of recurrent platinum-resistant ovarian cancer. Methods From January 1,2015 to December 31,2016,80 patients from Hunan Cancer Hospital with recurrent platinum-resistant ovarian cancer were divided into two groups by using random number table method,40 cases in each group:group PLD was treated with liposome doxorubicin and group G/ O was treated with gemcitabine combined with oxaliplatin. The therapeutic effects of the two groups were evaluated,the expressions of CA125 after treat-ment were compared and the occurrence of adverse reactions were observed. Results The objective response rate(ORR)and disease control rate(DCR)were respectively 27. 5％(11 / 40)and 35. 0％(14 / 40)in group PLD,and the ORR and DCR were respectively 22. 5％(9 / 40)and 27. 5％(11 / 40)in group G/ O,and there was no significant difference between the two groups(χ2 = 0. 27,P = 0. 61;χ2 = 0. 52,P = 0. 47). In PLD group and G/ O group,the CA125 values of ORR patients were(61. 27 ±28. 11)U/ ml and(78. 29 ± 34. 26)U/ ml respectively,with no significant difference(t = 1. 22,P = 0. 24),the CA125 values of non ORR patients were (530. 07 ± 77. 15)U/ ml and(551. 00 ± 78. 78)U/ ml respectively,with no significant difference(t = 1. 04, P = 0. 30). The main adverse reactions in group PLD were hand foot syndrome and myelosuppression. The main adverse reactions in group G/ O were gastrointestinal reaction and myelosuppression. The incidence rates of leucocyte reduction(65. 0％ vs. 92. 5％ ,χ2 = 9. 04,P = 0. 005),thrombopenia(15. 0％ vs. 52. 5％ ,χ2 = 12. 58,P < 0. 001),anemia(15. 0％ vs. 40. 0％ ,χ2 = 6. 27,P = 0. 012),gastrointestinal reaction (17. 5％ vs. 60. 0％ ,χ2 = 15. 22,P < 0. 001)and neurotoxicity(5. 0％ vs. 30. 0％ ,χ2 = 8. 66,P = 0. 006) in group PLD were lower than those in group G/ O,with significant differences. Conclusion The efficacy of two chemotherapy regimens is similar in patients with recurrent platinum-resistant ovarian cancer. Liposome doxorubicin has less adverse reactions than gemcitabine combined with oxaliplatin.
ABSTRACT
Objecfive To investigate the relationship between single nucleotide polymorphism-56(SNP-56)in calpain-10(CAPN-10)gene and polycystic ovary syndrome(PCOS)in Chinese.Methods The genotypes of SNP-56 of CAPN-10 were determined through polymerase chain reaction Tm-shift genotyping method in 638 local women in Shandong Province.Among them,334 were patients with PCOS (PCOS group)and 304 were normal women(control group).The baseline parameters including levels of serum follicle-stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E2),testosterone(T)and lipid,as well as the body mass index(BMI)and waist/hip ratio(WHR)were measured.Glucose tolerance and insulin releasing before and after loading with 75 g of glucose were also assayed.Results(1)The frequencies of two allelotypes or three genotypes did not differ between PCOS women and normal women(P＞0.05).(2)In PCOS group,patients with AA genotype had a significantly higher plasma glucose of 180 minutes OGTT(5.7±2.2)mmol/L[P＜0.01 compared to Gagenotype(4.9±1.2) mmol/L,P＜0.01 compared to GG genotype(4.9±1.4)mmol/L]and serum total cholesterol(TC)level(4.9±1.0)mmol/L[P＜0.05 compared to Gagenotype(4.5±0.9)mmol/L].(3)Compared to PCOS patients with GA+GG genotype(P＜0.05,P＜0.01)or GG genotype(P＜0.05,P＜0.01),there was significantly higher attack rate of diabetes and tumor in the family history of patients with AA genotype.Conclusions These findings suggest that CAPN-10 gene SNP-56 which may not contribute to the genetic susceptibility of PCOS plays a role in glucose and lipid metabolism in Chinese PCOS patients.It may also be correlated with attack rate of diabetes and tumor in the family history of PCOS patients.