ABSTRACT
Objective To investigate the psychological resilience and its influencing factors among patients after hepatectomy. Methods A total of 126 cases of hepatocellular carcinoma patients undergoing surgery eradication were selected. 1 d before the patients discharged,the general information was collected, the patients were investigated by using psychological elasticity scale, medical coping questionnaire, social support rating scale, quality of life measurement scale of liver cancer patients. The correlations between variables were analyzed by using Pearson correlation analysis. The influencing factors of psychological resilience were analyzed by using multiple linear regression equation. Results The overall psychological resilience score for patients after hepatectomy was (54.73 ± 10.61) points. The psychological resilience among patients after hepatectomy was related with age, educational level and postoperative hospital stay(t=2.959,3.452,2.507,P<0.05).Pearson correlation analysis showed that the psychological resilience among patients after hepatectomy was positively correlated with the confront coping, social support score, objective support, subjective support, supportive utilization, total quality of life, physical function, psychological function and social function (r =0.208-0.429, P<0.05), while was negatively correlated with avoiding coping, resignation coping, symptoms/side effects (r =-0.187,-0.442,-0.325, P<0.05). Multivariate stepwise linear regression analysis showed that resignation coping, subjective support, objective support, physical function and postoperative time entered the regression model and explained 59.4% of all the variation. Conclusions Patients after hepatectomy had poor psychological resilience, postoperative time, resignation coping, subjective support, supportive utilization and physical function were important influencing factors.
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OBJECTIVE:To study the spectrum-effect relationship of the antipyretic effect of Radix Bupleuri injection. METH-ODS:HPLC method was used to establish the fingerprint of Radix Bupleuri injection. The antipyretic effect of 10 batches of Radix Bupleuri injection on fever rats induced by dried yeast were determined respectively. The fingerprint peaks were screened,along with the temperature value of different time points(0,10,15,30,40,55,70 min). The principal components were extracted by principal component method and the indirect relationship between the fingerprint and antipyretic effect was analyzed,depending on the principal component correlation coefficient matrix. RESULTS:There were 39 common peaks in fingerprint(similarity>0.85), No. 8,12,14,19,26,31,34,35 and 39 common peaks with large peak area were included in the study. Four principal compo-nents were extracted by principal component analysis(87% of total variant). First principal component showed that the active com-ponents of the 12th peak may be related to the antipyretic effect of 6 to 13 hours. The second principal component showed that the active components of the 26th peak may be related to the antipyretic effect of 0.5 to 5 hours. The third principal component showed that the similar effect of the active components could be caused by 34th,35th and 39th peaks. The fourth principal component sug-gested that there were some similarities between the 14th and the 31st peaks. CONCLUSIONS:Radix Bupleuri injection have obvi-ous improvement for fever rats. There is certain corresponding relation between HPLC fingerprint and antipyretic effect of Radix Bu-pleuri injection .
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@#ObjectiveTo investigate the clinical feature peripheral neuropathy and vasculopathy after acrylamide toxication. Methods2 young male patients with peripheral neuropathy who had exposed to acrylamide for job more than one year were reported.ResultsNeuroelectrophysiological examination showed marked abnormalities in both peripheral and central nerve conduction in both patients. Sural nerve biopsies revealed axonal degeneration, Wallerian degeneration and giant axon with accumulated neurofilaments. Additonally, vasculopathies including prominant thickness of arterial intesma and basal membrane of capillary as well as apoptosis of vascular pericyte, were evident. ConclusionAxonal degeneration and vascular involvement has been found in acrylamide toxication. Vascular impairment maybe plays an important role in the pathogenesis of neuropathy.