ABSTRACT
To investigate the antiarrthritic activity of petroleum-ether extract of Portulaca oleracea. The petroleum-ether extract of Portulaca oleracea was subjected to preliminary phytochemical screening. Acute toxicity studies were carried out in Male Wistar rats and anti-arthritic activity by Fruends adjuant arthritis model. Phytochemical evaluation revealed the presence of alkaloids, tannins, flavonoids, saponins and triterpenoids. Acute toxicity studies showed that the extract was non-toxic upto a maximum dose of 2000 mg/kg body weight. Petroleum-ether extract exhibited significant anti-arthritic activity. The present study indicates that the petroleumether extract of Portulaca oleracea has a potential anti-arthritic activity can be used as anti-arthritic drug.