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Hindustan Antibiot Bull ; 1994 Feb-May; 36(1-2): 34-8
Article in English | IMSEAR | ID: sea-2430

ABSTRACT

Polyene antibiotics are known for their remarkable antifungal properties. The alkali metal and quaternary alkylammonium salts of amphotericin B, nystatin and aureofungin have been prepared by ion-exchange method. The physico-chemical and biological properties of these salts have been studied with a view to evaluate their therapeutic advantages over the parent compounds. While the majority of the salts reported herein showed more water solubility; triethylammonium salts, unlike the other alkali metal salts, possessed marginally improved or similar bioactivity in comparison to their parent antibiotic having reduced toxicity.


Subject(s)
Amphotericin B/chemistry , Antifungal Agents/chemistry , Candida albicans/drug effects , Chemistry, Physical , Metals/chemistry , Nystatin/chemistry , Chemical Phenomena , Polyenes/chemistry , Quaternary Ammonium Compounds/chemistry
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