Chryseobacterium Indoloegenes Meningitis in a Patient with Ventriculo-peritoneal Shunt.

Chryseobacterium indologenes organism is mostly confined to water and soil and has been isolated from patients in hospitals with severe underlying disease with indwelling devices and implants. Despite its low virulence, it has been found to be inherently resistant to many antibiotics. A rare case of meningitis was reported by C. indologenes in an 18-year-old patient treated for hydrocephalous with meningitis with an indwelling ventriculoperitoneal shunt, who was successfully managed with levofloxacin and gentamicin and discharged. This case report describes identification and isolation of C. indologenes on the basis of biochemical and microbiological analysis along with clinical signs and symptoms of meningitis with an indwelling ventriculoperitoneal shunt.

Isolation and characterization of actinomycetes from soil and evaluation of antibacterial activities of actinomycetes against pathogens.

Actinomycetes are one of the most attractive sources of antibiotics. In the present studies, total of 15 strains were isolated from Dr. Ram Manohar Lohia Hospital and RML Park in Lucknow, U.P India. Isolated strains were identified for their antibacterial activity but only six isolate showed good result, they were evaluated for their inhibitory activity on 3 strains of microorganism (E. coli, P. aeruginosa and S. aureus). Isolation of Actinomycetes strain was obtained by serial dilution method and grown on actinomycetes isolation agar. Antibacterial compounds were produced by submerged fermentation and activity of compounds were checked against bacterial culture by antibiogram analysis where intracellular and extracellular compounds showed positive result, compare to intracellular compounds, extracellular compounds was showing best result which was 30 mm zone of inhibition against S. aureus and MIC was found to be 0.0009 mg/ml.