ABSTRACT
INTRODUCTION: Adenoid cystic carcinoma (ACC) of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site. The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma. METHODS: A retrospective chart review was performed at a tertiary referral center between 2010 and 2015, 15 patients were evaluated for ACC of the sinonasal tract at a single institution. demographics, presentation, anatomic site, tumor, lymph node, metastasis (TNM) classification, pathology, treatment, recurrences, and survival were evaluated. RESULTS: The median age of patients was 52 years, and the mean follow–up was 36 months. The maxillary sinus (46.6%) and the nasal cavity (33.3%) were the most common primary tumor sites. The majority of patients presented with T3/T4 (73.3.7%) without any nodal and distant metastasis. All the patients underwent surgery and received postoperative radiation as treatment for their primary disease. The local recurrence rate was 40%. CONCLUSION–ACC of the sinonasal tract is a rare tumor. Poor prognostic factors that affect survival include tumor site, extent of invasion, stage, histopathologic type and grade. The current data suggested that surgical resection with postoperative radiation therapy offers durable local control and compares favorably with historic data. Since local recurrences develop in a significant percentage of patients, therefore, the ideal treatment paradigm has yet to be defined. However survival from this disease exceeds that of other sinonasal malignancies.
ABSTRACT
Background & objectives: Imbalances in compactly regulated DNA repair pathways in the form of single nucleotide polymorphisms (SNPs) within vital DNA repair genes may result in insufficient DNA repair and increase in DNA breaks thus rendering the human system vulnerable to the debilitatory effects of grave diseases like cancers. The present study involves investigation of association of the non-synonymous SNP rs1052133 (C8069G/Ser326Cys) located in the exonic region of the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head and neck (SCCHN). Methods: Case-control based genetic association study was performed among 575 (250 SCCHN cases and 325 normal healthy controls) sub-population cluster-matched (Indo-Europeans linguistic subgroup + Caucasoid morphological subtype) samples from the north Indian States of Uttar Pradesh and Uttarakhand using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis. Results: Our results demonstrated statistically significant protective association for the heterozygous CG [Odds Ratio (OR) 0.6587, 95% Confidence Interval (CI) 0.4615 to 0.9402, P=0.0238], homozygous mutant GG (OR 0.2570, 95% CI 0.1070 to 0.6175, P=0.0013) and combined mutant CG + GG (OR 0.6057, 95% CI 0.4272 to 0.8586, P=0.0059) genotypes. Interpretation & conclusions: The results indicate that the polymorphism rs1052133 is strongly associated with SCCHN susceptibility and the mutant (G) allele might be a protective factor for SCCHN among north Indian subpopulations.
Subject(s)
Carcinoma/enzymology , Carcinoma/genetics , Carcinoma/pathology , Carcinoma, Squamous Cell , Case-Control Studies , DNA Glycosylases/genetics , DNA Repair , Databases, Genetic , Genetic Predisposition to Disease , Genotype , Head and Neck Neoplasms/enzymology , Head and Neck Neoplasms/genetics , Head and Neck Neoplasms/pathology , Humans , India , Neoplasms, Squamous Cell/enzymology , Neoplasms, Squamous Cell/genetics , Neoplasms, Squamous Cell/pathology , Polymorphism, Single Nucleotide , Risk FactorsABSTRACT
A case of massive ovarian edema and polycystic ovaries in a 15 years old girl is being reported for its rarity. Definitive preoperative diagnosis is often not achieved and there by the patient is at a risk of losing the ovary(ies). Thus a definitive preoperative diagnosis should be ascertained to save the organ. A review on the previously reported cases with probable etiopathogenesis and emphasis on the radiological and morphological diagnosis for appropriate management has been discussed.