ABSTRACT
Background & objectives The prevalence and incidence of ischemic heart disease virtually ubiquitous among most developed nations and in India. Considerable progress on the health impact of atherosclerosis disease has been made over recent decade and being largest cause of mortality and morbidity in country like India. The study highlights the impact of atherosclesis lesion in population Bhavnagar Gujarat. Method: Study comprise of 300 specimen of heart subjected to autopsy, to grade and to evalue athermanous plaque and myocardial infarction. The atherosclerotic lesions were graded according to American heart association classification. Results: The study show significant atheroma that was grade IV (29.7%), grade V (29%) and grade VI (21.7%). Triple and double vessels involvement was seen in 43.7% and 39.6 % cases respectively. The changes of myocardial infarction were found in 31 cases. Conclusion: The study highlights the impact of atherosclerotic lesions in the population of Bhavnagar,Gujarat.The incidence of atherosclerosis is more in male as compare to female. The study show increase incidence of atherosclerosis in younger people in third decade The evaluation of the study may form baseline for research and forthcoming study.
ABSTRACT
Aim & Objective: To evaluate the usefulness of estimation of ADA (Adenosine deaminase) activity for etiological diagnosis of pleural effusion & to study the level of pleural fluid ADA in tuberculous & nontuberculous pleural effusion & establish cutoff limit of ADA activity. Materials & Methods: Present study was conducted in pathology department Pandit Dindayal Upadhyay Medical College Rajkot during year July 2005 to September 2007 for which we have taken 100 patients of all ages & either sex admitted in various medical wards, T.B. ward and O.P.D. Spectrophotometric method was used for ADA estimation. Results: The present study was carried out in 100 patients out of which 78 patients were of tuberculous pleural effusion & 22 cases were of Non-TB pleural effusion. There was minor difference in male & female Pleural Fluid (Both TB & Non TB) Mean ADA Level. Most of Tuberculous Effusion was in Range of 40-60 U/L ADA level (64 Pts) while Non Tuberculous effusion was between 16-20 U/L of ADA level (14 Pts). At level of 35 U/L of cut-off limit of ADA in pleural fluid sensitivity & specificity would be 94.7% & 72.7% respectively. Conclusion: The study concluded that estimation of ADA in Pleural Fluid is simple, rapid & less expensive laboratory investigation for diagnosis of tuberculous pleural effusion when diagnosis is uncertain by other investigation & it has valuable role as an adjuvant investigation to other diagnostic investigation of Tuberculosis.