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1.
Chinese Herbal Medicines ; (4): 92-95, 2017.
Article in Chinese | WPRIM | ID: wpr-842210

ABSTRACT

Objective To study the biotransformation regulation and pharmacological effect of swertiamarin and its metabolite in incubated system of human intestinal flora. Methods Incubated system of human intestinal flora was utilized to research the intestinal metabolism of swertiamarin. Furthermore, mutagenic test and anti-mutagenic test were carried out to research the activity relationship of swertiamarin and its metabolite. Results Gentianine was found in the metabolites of swertiamarin. The pharmacological experiment indicated that swertiamarin and its metabolite both had good anti-mutagenic effect. Conclusion Swertiamarin is partly metabolized to gentianine after oral administration. They show similar anti-mutagenicity effects.

2.
Chinese Pharmaceutical Journal ; (24): 1545-1549, 2013.
Article in Chinese | WPRIM | ID: wpr-860227

ABSTRACT

OBJECTIVE: To study the quality control method of Swertia mussotii Franch. METHODS: A high performance liquid chromatographic method was developed to establish the fingerprint of Swertia mussotii Franch. Nineteen samples from various batches were analyzed, furthermore, PCA were used to differentiate and evaluate the whole fingerprints. Some characteristic peaks were i-dentified preliminarily with HPLC-MS method. RESULTS: Eleven peaks were identified by MS. Swertiamarin and swertianolin were the key components for quality control. CONCLUSION: The method provides an academic reference for controlling the quality of Swertia mussotii Franch.

3.
China Journal of Chinese Materia Medica ; (24): 3743-3747, 2012.
Article in Chinese | WPRIM | ID: wpr-346846

ABSTRACT

<p><b>OBJECTIVE</b>To study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.</p><p><b>METHOD</b>Total terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS.</p><p><b>RESULT</b>Eight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon.</p><p><b>CONCLUSION</b>Total terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.</p>


Subject(s)
Humans , Alkaloids , Metabolism , Anaerobiosis , Bacteria , Metabolism , Chromatography, High Pressure Liquid , Intestines , Metabolism , Microbiology , Ketones , Metabolism , Mass Spectrometry , Swertia , Metabolism , Terpenes , Metabolism , Xanthones , Metabolism
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