Research progress on the role and mechanism of endothelial dysfunction in hyperhomocysteine-induced atherosclerosis / 生理学报

Hyperhomocysteinemia (HHcy) is considered to be an independent risk factor for cardiovascular diseases, but the molecular mechanisms underlying its pathogenesis are not fully understood. Endothelial dysfunction is a key initiating factor in the pathogenesis of atherosclerosis, which is commonly observed in almost all HHcy-induced vascular diseases. HHcy promotes oxidative stress, inhibits nitric oxide production, suppresses hydrogen sulfide signaling pathway, promotes endothelial mesenchymal transition, activates coagulation pathways, and promotes protein N-homocysteination and cellular hypomethylation, all of which can cause endothelial dysfunction. This article reviews the specific links between HHcy and endothelial dysfunction, and highlights recent evidence that endothelial mesenchymal transition contributes to HHcy-induced vascular damage, with a hope to provide new ideas for the clinical treatment of HHcy-related vascular diseases.

New Discussion on Knowledge Route and Dialectical Map of Clinical Medical Records in TCM Classics / 中国中医药信息杂志

Medical records in TCM classics refer to specific records that doctors follow in the process of clinical diagnosis of patients through clinical dialectical thinking and diagnosis and treatment. In ancient times, there are representative works of medical records, and different periods of medical writings have different ways of compiling and writing, with representative significance in the history of China. This article summarized the knowledge route and dialectical map of TCM clinical medical cases,and summed up the following conclusions:Shi Ji is the earliest record of TCM records;Pu Ji Ben Shi Fang uses medical case as evidence of clinical experience;Shang Han Jiu Shi Lun is the world's first book of narratives of medical records;Xiao Er Yao Zheng Zhi Jue is the world's first systematic case compile for pediatrics;Xi Yuan Ji Lu is the world's first book of forensic medicine;Ming Yi Lei An is the world's first TCM medical case book with medical cases of different schools;Lin Zheng Zhi Nan Yi An is an important medical book of epidemiology; Gu Jin Yi An An creates comprehensive review of ancient and modern medical cases; Jing Fang Shi Yan Lu is the most representative formula records in Shang Han Lun.