Effect of prednisolone on LPS-induced RANTES production / 西安交通大学学报(医学版)

Objective To study the effect of prodnisolone on lipopolysaccharide(LPS)-induced RANTES by microglia.Methods The microglia were incubated in MEM culture medium,and different concentrations of LPS 0,100,500,1000?g/L) or LPS(100?g/L) and prodnisolone(10?mol/L) were added into the culture medium.12h later,the amount of RANTES was measured by ELISA.Results Microglia markedly produced RANTES in response to LPS.Prodnisolone significantly reduced the production of RANTES in microglia.Conclusion Prodnisolone has an inhibitive effect on the production of chemokines such as RANTES.

EEG AND CLINICAL MANIFESTATION OF NERVOUS SYSTEM IMPAIRMENT BY PULMONARY TREMATODIASIS / 西安交通大学学报(医学版)

The clinical manifestation and EEG of 20 cas-es of the patients with damage to nervous systemby pulmonary trematoaiasis are analyzed in the ar-ticle. Those cases made up 30. 3% of the totalnumber of the patients suffered form pulmonarytrematodiasis treated during the same period of thetime. Their clinical signs and symptoms, apartfrom those of Lungs, of skin, and of muscule,were headache, hemiplegia, aphasia, epilepsy,haemorrage in the subarchnoid space and impair-ment of multiple cranial nerves. besides, therewas also a case with damage to the spinal cord. Cases with abnormal EEG constituted 95. 4%of the patients with brain damage. The degree ofthe EEG abnomality varied from case to case ac-cording to the severity and extent of the lesions inpatient brains. Generally speaking, the abnormali-ty of EEG in the cases with cerebral impairmentwas more severe than that in the cases with dam-age only of meningeal. In the cases with circum-scribed granuloma formation the abnormal EEG al-so showed localization. Just for those reasons, authors believe that acontineous check up of EEG is more helpful in pre-dicting the involvement of lesion in the brain, theseverity of the damage and even the outcome of thedisease.