ABSTRACT
Objective To analyze the features of hypertensive retinopathy (HRP),and to evaluate the correlation of serum cystatin C (Cys-C) and retinopathy in patients with primary hypertension.Methods From July 2015 to October 2017,280 cases of primary hypertension in the Second People's Hospital of Ji'nan were recruited to receive fundus examination by funduscopy and eye-ground photography.Based on the findings,4 groups were established according to Chinese Ophthalmology (Third Edition) classification standard,normal,mild,moderate and malignant four levels.Clinical courses were monitored and Cys-C levels were determined.Results There were 204 cases of HRP,accounting for 72.86％.Compared with that of the normal fundus group (0.76 ±0.12)mg/L,the serum Cys-C level of the mild HRP group was (0.82 ± 0.19)mg/L,the difference was statistically significant (t =2.424,P ＜ 0.05).The serum Cys-C levels of the moderate HRP group and severe HRP group were (2.37 ± 0.13) mg/L and (3.24 ± 0.45) mg/L,respectively,the differences were statistically significant compared with that of the control group (t =80.917,42.153,all p ＜ 0.01).Conclusion The severity of HRP is positively correlated with Cys-C.
ABSTRACT
Objective To explore the effect of amlodipine atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease complicated with carotid atherosclerosis .Methods From August 2013 to August 2017,280 patients with hypertension and coronary heart disease complicated with carotid atherosclerosis in the Second People＇s Hospital of Ji＇nan were selected,and they were divided into two groups by envelope randomization packet mode,with 140 cases in each group.The control group was treated with amlodipine benzenesulfonate.The observation group was treated with amlodipine atorvastatin calcium tablets .The incidence of adverse reactions,diastolic blood pressure (DBP) level,systolic blood pressure (SBP) level,total effective rate,hs-CRP,TC,TG,HDL-C,LDL-C,IMT,PV were compared between the two groups.Results There were no statistically significant differences in PV,IMT,SBP and DBP between the two groups (t ＝1.150,0.861,0.195,0.637,all P＞0.05).The incidence rate of adverse reactions (2.86%),DBP level[(78.95 ±3.11)mmHg],SBP level[(121.63 ±5.42)mmHg],total effective rate (96.43%),hs-CRP levels[(4.15 ±1.65)mg/L],TC level [(3.28 ±1.98)mmol/L],TG level[(1.22 ±0.34)mmol/L],HDL-C level[(1.98 ±0.75)mmol/L],LDL-C level[(1.33 ±0.54)mmol/L],IMT[(1.12 ±0.05)mm],PV[(0.11 ±0.03)cm3]in the observation group were better than those in the control group (χ2＝22.630,t＝15.839,37.209,χ2＝25.053,t＝20.056,7.381,8.659,15.110,21.951,15.665,12.951,all P＜0.05).Conclusion The effect of amlodipine atorvastatin calcium tablets in the treatment of patients with hypertension and coronary heart disease complicated with carotid atherosclerosis is remarkable.