ABSTRACT
Objective:To investigate the effect and related mechanism of quetiapine fumarate tablets combined with valproate sodium tablets in the treatment of depression, and its influence on quality of life.Methods:From January 2017 to January 2019, 96 patients with depression admitted to the Second People's Hospital of Lishui were divided into control group ( n=48) and observation group ( n=48) according to the random digital table method.The patients in the observation group were treated with quetiapine fumarate tablets combined with sodium valproate tablets, while the patients in the control group were treated with sodium valproate.Both two groups were treated for 8 weeks.The therapeutic efficacy, Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale (HAMD), 5-HT, substance P (SP), neuropeptide Y (NPY) and World Health Organization Quality of Life Scale (WHOQOL-BREEF) were compared before and after treatment. Results:The total effective rate of the observation group (91.67%) was higher than that of the control group (70.83%) (χ 2=6.838, P<0.05). After treatment, the scores of PSQI and HAMD in the observation group[(8.74±1.29)points and (14.35±1.37)points] were lower than those in the control group [(10.85±1.43)points and (21.19±2.09)points] ( t=7.591, 18.963, all P<0.05). After treatment, the serum levels of 5-HT [(43.17±7.46)μg/L] and NPY [(7.98±0.43)mg/L] in the observation group were higher than those in the control group [(34.36±5.18)μg/L and (6.59±0.37)mg/L], while the SP level [(3.98±0.54)mg/L] in the observation group was lower than that in the control group [(5.43±0.67)mg/L], the differences were statistically significant( t=6.721, 16.976, 11.674, all P<0.05). After treatment, the scores of environmental field [(65.78±2.63)points], social relationship[(60.31±3.25)points], psychology[(71.83±3.15)points] and physiology [(69.83±3.56)points] in the observation group were higher than those in the control group [(58.91±2.35)points, (54.73±2.32)points, (64.36±2.78)points, (61.15±2.89)points]( t=13.495, 9.682, 12.319, 13.115, all P<0.05). There was no statistically significant difference in adverse reactions between the two groups ( P>0.05). Conclusion:Quetiapine fumarate tablets combined with sodium valproate tablets is effective in the treatment of depression, which can increase serum 5-HT and NPY levels and decrease SP level, and improve the quality of life of patients.
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ObjectiveTo explore the clinical effect of transcatheter hepatic arterial chemoembolization and systemic chemotherapy on colorectal cancer with hepatic metastasis.Methods50 cases of colon cancer with hepatic metastasis according to treatment methods were divided into A,B group.A group treated by TACE plus intravenous chemotherapy,B group treated by intravenous chemotherapy alone.Side effects,changes in liver tumor size and survival rate were observed.ResultsThe incidence of side effects of two groups had no significant difference ( P ＞ 0.05 ).A group of liver lesions smaller in size or stable is more than in group B( P ＜0.05 ).A group of 1 year,3 years survival rate is 84％and 64％respectively,which is higher than B group 56％and 36％ ( all P ＜ 0.05 ).ConclusionTranscatheter hepatic arterial chemoembolization and systemic chemotherapy is a safe and effective treatment of colon cancer with hepatic metastasis,it can obviously raise the survival rate.
ABSTRACT
Objective To analyze the effect and safety of interventional therapy by trans uterine artery for treatment of tubal pregnancy. Methods Forty-two patients with tubal pregnancy were performed two side uterine arteries. MTX perfusion and embolization with gelfoam particles guided by DSA fluoroscopy. Results Forty patients obtained the decline of serum β-HCG value and 39 patients' ectopic mass absorption after treatment. Two patients occurred ectopic mass bleeding after interventional therapy and emergency surgical operation were done, but the amount of bleeding was low than 400ml. Conclusion Interventional therapy by trans uterine artery for treatment of tubal pregnancy could preserve the function of fallopian tubal, it was more benefit for patients who want normal pregnancy.