ABSTRACT
Regulatory non -coding RNA is a kind of non -ncoding RNA which has regulatory effect,play an important role in the development and plasticity of the human nervous system,and related to the pathogenesis of nervous system diseases.Hirschsprung′s disease(HD)is the the most common diseases associated with digestive tract pediatric deformity,at present the causes are not clear,generally considered the etiology of HD is the enteric nervous system (ENS)abnormal development of embryonic period,through the in -depth research of regulatory non -coding RNA in human nervous system development,finding that there is a close relationship between the regulatory non -coding RNA and nosogenesis of HD.This provides a basis for studying of the pathogenesis of HD.In this paper,research progress on regulatory non -coding RNA in the pathogenesis of HD are reviewed and this paper explore the role of RNA in HD,it provides a new target in the early diagnosis and treatment of HD.